ABSTRACT
Introduction: Although caesarean section as a way to save both mother and child has been accepted in an emergency state, but its harmful consequences such as infectious diseases, anesthesia complications, and postpartum depression which could be a threat to the health of the mother, child, family and the community. The aim of this study was to investigate the factors associated with cesarean delivery choice among pregnant women living in the city of Jiroft
Methods: A cross-sectional study was conducted on 145 pregnant women attending public and private medical centers in Jiroft. Data collection instrument was a questionnaire designed by the researchers. The validity of the questionnaires was confirmed and the reliability was assessed using Cronbachs alpha coefficient which was 84%. Data were analyzed by SPSS v.19 and Logistic regression test was used [p-value=0.05]
Results: The mean age of the study participants' was 4 +/- 34 years and 75% of the women in the study chose cesarean delivery as the best method. Most participants in the study were pregnant for 7 - 5month [35.25%] and experienced the first pregnancy [44.1%]. The majority of them [52.4%] reported friends and family as a source of information for choosing cesarean section as the delivery method. The results of logistic regression showed that the location of prenatal care, abortion, economic status, place of birth, family history of cesarean delivery, and previous cesarean were significantly related with choosing cesarean as the delivery method
Conclusion: A high percentage [75%] of participants in this study had chosen cesarean section as the delivery method. Therefore, authorities should consider it as a public health problem. A way to overcome this problem is increasing the awareness of pregnant women of normal delivery benefits through the education
ABSTRACT
Oligodendrocytes are myelinating cells in the central nervous system [CNS] which develop from oligodendrocyte progenitor cells [OPCs]. Opalin is a unique molecular marker for mature and myelinating oligodendrocyte. Olig1/2 plays a regulatory function in the differentiation of OPCs to oligodendrocyte. Ciliary neurotrophic factor [CNTF] has been shown to play an important role in the proliferation and maturation of oligodendrocytes. In this study the effects of CNTF on Opalin, Olig1/2 expression in the cerebral cortical extracts of Cuprizone induced multiple sclerosis [MS] has been investigated. The mice were treated by Cuprizone for five weeks in order to induce MS. The mice were then divided into 3 groups. The first group was injected subcutaneously [SC] by CNTF in the amount of 2 microg/kg BW. The second group [SHAM] was injected SC by phosphate buffered saline [PBS] and the third group was left without injection as the control group. After five weeks the mice were killed and the cerebral cortex was harvested and the expression of Opalin and Olig1/2 was studied by Western blotting. The results from this study show that the expression of Opalin, Olig1/2 was significantly increased in the CNTF injected group as compared to the other groups. It is concluded that CNTF enhances Opalin, Olig1/2 expression and may play important role in the pathophysiology of MS. It is also concluded that CNTF may be a regulator in the differentiation of oligodendrocyte from OPCs