ABSTRACT
Multifocal tuberculosis [TB] is rare. It occurs especially in immunocompromised patients. Association with skin involvement is rarer, and few cases are reported in the literature. The present study reports 7 cases of multifocal TB with cutaneous localization in immunocompetent patients. Cutaneous forms of TB included in this series are: gummas, scrofuloderma, vasculitis TB and lupus TB. The patients had at least two extra skin locations, namely: osteoarticular, lung, pleural, scrotal, muscular, digestive, laryngeal, nodal and splenic locations. These patients had no context of immunosuppression which is uncommon, but should be kept in mind, especially in endemic countries
ABSTRACT
Scleroderma is uncommon in childhood. The aim of our study was to analyse the frequency of different clinical forms, their prognostic significance and to assess the pertinence of therapeutic options. Patients and method: It is a retrospective study concerning 25 cases of scleroderma in childhood and colliged in the Dermatology Unit of Rabat Ibn-Sina University Hospital Center between 1985 and 2003, excluding patients older than 15 year-old. Localized scleroderma was observed in 18 children and diffuses lesions in 7 children. Localized scleroderma began at a mean age of 10 year-old. The lesions were isolated bands [44%], associated with morphea [11%], or multiple morphea [11%]. Mean duration of the clinical course was longer in cases with more and deeper lesions. Eosinophilia was observed in 11% of cases and antinuclear antibodies were found in 22% of cases. Local and general corticosteroids appeared to be efficient in superficial and active lesions. Diffuse scleroderma began at mean age of 11 year-old. The therapeutic problems were similar to those in adults. In conclusion, scleroderma prognosis depends on functional impairment resulting from major sequelae of localized forms and the life-threatening situations occuring in systemic forms