Synthesis and Hypolipidemic Activity of Some New Dibenz [c,e] azepine Deravatives

Some new 6-substituted 5H-dibenz[c,e]azepine-5,7[6H]-diones [VII] were synthesized and tested for possible hypolipidemic activity. Thus anthranilic acid [I] was converted to diphenic acid [II] which was cyclodehydrated to give diphenic anhydride [III]. Ammonolysis of [III] afforded diphenamic acid [IV] which was cyclodehydrated to yield diphenimide [V]. Potassium salt of [V] was condensed with chloroacetic acid, ethyl chloroacetate or N-substituted and unsubstituted chloroacetamides to produce the target compounds [VII]. The preliminary evaluation of the hypolipidemic activity of [VII] against Triton WR 1339-induced hyperlipidemia in rats showed that several derivatives have demonstrated significant lowering of serum total cholesterol and triglyceride levels at dose of 150 mg/kg comparing with clofibrate

Pulmonary haemodynamic changes after injection sclerotherapy in patients with bilharzial pulmonary hypertension

This work aimed to evaluate the incidence of bilharzial pulmonary hypertension [PH] in patients with ruptured esophageal varices, as well as the value of variceal injection as a therapeutic modality and its effects on pulmonary hemodynamic, among patients with bilharzial PH. Out of 3000 patients with ruptured esophageal varices, 18 only were found to have associated bilharzial. Patients with ruptured varices and bilharzial PH were subjected to emergency sclerotherapy to control bleeding, repeated sclerotherapy to produce variceal obliteration and electrocardiographic as well as Doppler echocardiographic evaluations and estimation of mean pulmonary artery pressure [MPAP] for 3 times [before initial sclerotherapy, 1 week after control of bleeding and 1 week after complete variceal obliteration]. Injection sclerotherapy had resulted in non- significant changes in all the studied electrocardiographic and Doppler echocardiographic parameters among our patients with bilharzial PH. It had resulted also in non significant lowering in MPAP among them

effects of a hemodialysis session on left ventricular function in patients with chronic renal failure under maintainance hemodialysis

The effects of a haemodialysis session [D. S] on the left ventricular function [LVF] were studied in 31 patients [77% males and 23% females] with end stage renal failure. Their mean age was 30. 4 +/- 7 83 years [17- 42 years] and they have been on maintainance haemodialysis for 2 months to 5 years [mean duration 19. 9 +/- 13. 61 months]. Echocardiograhic study revealed that the D. S. resulted in significant decrease [P< 0.05] in the mean end systolic diameter and volume; mean end diastolic diameter, end diastolic volume and volume index. Similarly, there was a significant decrease in the mean stroke volume and mean left ventricular ejection time. In the mean time, there was a significant increase in the mean ejection fraction and the mean circumferential fiber shortening velocity. It was evident from our work that, the D. S resulted in partial correction of serum electrolytes imbalance and metabolic abnormalities. There was a consequent improvement in the echocardiographicaly determined L VF [as reflected by decrease in left ventricular dimensions and volumes] with better contractility. Accordingly, it can be assumed that, the disturbed left ventricular cardiac functions found prior to dialysis are mainly due to functional rather than structural changes

Echocardiographic and electrocardiographic short term effect of thrombolytic therapy in acute myocardial infarction

This prospective study was conducted in order to evaluate short term effects of thrombolytic therapy, in patients with AMI, on clinical, electrocardiographic and echocardiographic parameters. Sixty seven patients with AMI were randomized into 2 groups, test group treated with IV/SK and control group treated with conventional therapy. From the comparative analysis, the test group and its different subgroups show less incidence of recurrent chest pain and LVF, rapid resolution of electrocardiographic S-T segment and higher E.F as compared to control. Also, the earlier the start of thrombolytic therapy the more prominent this good progorestic changes So, it is mandatory to use this line of treatment on a wide scale in patients with AMI very early the prehospital phase if, possible, in order to improve the prognosis of such fatal disease