Orthodontic tooth movement and root resorption after different doses of celecoxib drug treatment in rats

Non- Steroidal Anti Inflammatory [NSAIDs] medications used for treatment of pain related to orthodontic treatment could slow down tooth movements. Selective cyclooxigenase- 2 inhibitors are alternatives to conventional non steroidal drugs. The aim of this study was to compare three different doses of Celecoxib on orthodontic tooth movement and root resorption in Rats. Forty male Rats randomly divided into the following groups; D [the application of orthodontic appliance with taking medications]; E [without any intervention] and experimental groups included A [received 25 mg/kg], B [received 50 mg/kg] and C [received 100 mg/kg] dose of Celecoxib. NiTi coil spring was ligated between the right side maxillary incisor and 1[st] molar. The animals were sacrificed after two weeks and distance between 2 teeth was measured with Caliper. After preparation of histological sections, amount of root resorption, numbers and maximum depth of resorption lacunae in mesial root surfaces of molar was measured. Data were analyzed with ANOVA, LSD and Tukey HSD. The maximum tooth movement was found in group A [0.8537 mm], D, C, B and E respectively. Statistical analysis did not show any significant difference between the different doses of Celecoxib drug in tooth movement. The usage of Celecoxib [particularly in higher doses; 100 mg/kg] decreased the number of resorption lacaunae in mesial root of first maxillary molar [P< 0.05]. 100 mg/kg dose of celecoxib was found to be optimum for the lowest effect on tooth movement and the most protection against root resorption

[Oral health related quality of life among Iranian children: Part I - Validity, reliability, prevalence and seventy assessment of daily impact factors]

Given the current need for studies evaluating oral health related quality of life among the Iranian children, this study was designed to test the validity and reliability of a Persian version of Child-OIDP index and also evaluate the prevalence and impact of oral disorders on the quality of life of 11-14-year-old Iranian children. In this cross-sectional study, after translation of Child-OIDP instrument into Persian language, the psychometric properties of this index were evaluated in terms of face, content and construct validity. In addition, the internal and test-retest reliability were evaluated. A sample of 384 Iranian children aged 11-14-years old completed the instrument via a face-to-face interview. Each interview was followed by a clinical examination as well as completion of a self-administered questionnaire providing the information on demographic and oral health behaviors. The Persian version of Child-OIDP demonstrated excellent validity and reliability. The index showed significant associations between perceived oral treatment needs and perceived satisfaction regarding their oral cavity [P<0.001]. ICC was 0.784, and Cronbacrf s alpha was 0.59. About 54% of children reported dental disorders over the past 3 months that impacted on daily performances, according to Child-OIDP index. The most prevalent affected activities were eating and oral hygiene performance. The most prevalent oral disorder leading to impact were sensitivity tooth and gingival bleeding. Based on the results of this study, it can be concluded that the Persian version of Child-OIDP index is a valid and reliable instrument for evaluation of oral health-related quality of life as applied to Iranian children. The prevalence of oral impacts was moderate. The pattern of impacts differed according to the type of self-perceived oral problem