ABSTRACT
The present study included 20 patients with atopic dermatitis [AD]. These patients comprised 2 groups; the first group included 10 patients with only AD [pure AD], the second group included 10 patients with AD and respiratory manifestations of bronchial asthma [AD with BA]. These patients as well as 10 normal individuals as a control group were subjected to HLA typing using lymphocyte microcytotoxicity testing. Serum total IgE was determined in the patients and control group. The results of the present study showed no significant difference between patients and control. The results of HLA typing of patients subgroups [only AD, AD with BA] were compared to control. It was found that HLA-A1 was significantly higher in patient groups in comparison to control group as P <0.05 and P <0.01, respectively. HLA-B8 was not significantly higher in patient groups in comparison to control as RR was 0.58 and 1, respectively. HLA-A3 was significantly increased in patient groups in comparison to control as P <0.05 and P <0.05, respectively. HLA-B7 was significantly increased in patient groups in comparison to control as P <0.01 and P <0.01, respectively. The present study also revealed the serum total IgE to be significantly increased in both groups of patients in comparison to control group. It was evidented that the amount of serum total IgE in cases of AD is much less than that in cases suffering from AD with BA. These results were discussed