ABSTRACT
The interaction of carrageenan [Aubygum x 23] with chlorpheniramine maleate in aqueous medium was studied. The effect of drug conception, polymer [Aubygum x 23] concentration, electrolytes and pH on the extent of such interaction was investigated. It was found that the percentage of drug interacted with the polymer increases with increasing polymer or drug concentration. On the other hand, the presence of electrolytes decreased the interaction between the drug and the polymer. Such decrease in the interaction was found to depend on the concentration of electrolyte added and its valency. The interaction was found to be pH dependent and the optimum pH was found to be 7. The m.p. and solubility of the interaction of product were found to differ from the m.p. and solubility of the original compounds [chlorpheniramine maleate and Aubygum x 23]. IR analysis showed that there is a very powerful interaction induced via hydrogen bonding and large polarity of the produced mixture