Diagnosis and management of luteinized unruptured follicle [LUF] syndrome

A diagnosis of LUF syndrome in 490 women of unexplained infertility was made sonographically by failure to demonstrate a minimum of 5 mm reduction in follicular diameter with a change in the follicular and endometrial echogenecities within 48 hours after LH surge in urine. Fifty patients with LUF were categorized into three groups: 10 patients received only hCG for rupture of follicle, 30 patients were given clomiphene citrate therapy, then received hCG and 10 women having LUF syndrome did not receive any ovulation inducing drugs as a control group. The study concluded that the use of clomiphene citrate in LUF women increased the chance of ovulation by using 10,000 IU hCG with an increased chance of pregnancy