Posttherapeutic outcome of patients with abdominal non-hodgkin's lymphomas

This study included 152 patients with abdominal non-Hodgkin's lymphomas whether the abdomen was the primary site or involved later in the course of disease, regardless of their age or sex. Patients were treated at Tanta University Hospitals during the period from January 1990 to December 1995 inclusive. They were 93 males and 59 females with 1.6:1 ratio. The most common presenting symptom were abdominal pain [74.3%] and nausea and vomiting [11.8%], while only one patient in pediatric age presented with intestinal obstruction. None of cases showed primary liver involvement, but with involvement elsewhere and enlarged spleen was found in 108 cases and two cases with renal involvement and one case with neurological manifestations due to brain affection. In the present study, surgical removal of gastrointestinal tract [GIT] lymphomas was one of the prognostic factors as a debulking procedures. The presence of B-symptoms inversely affect the outcome and patients with nodular lymphomas had better survival than those with diffuse type. Abdominal irradiation as adjuvant to chemotherapy prolonged local control rates with improved survival. The aim of this work is to study presentations, pathological types, distribution and results of management of abdominal non-Hodgkin's lymphomas

Effect of postoperative therapy on prognosis of large bowel cancer

Through a period of 7 years [from September 1987 to August 1994 inclusive] 82 patients with colonic or rectal cancer were treated at Radiation Oncology Unit, Tanta University Hospitals. They represent 2.9% of all cases and 64% of all gastrointestinal tract [GIT] tumors. They were 48 males and 34 females with a mean age of 41.2 +/- 8.32 years. The most common presenting symptoms were disturbed bowel habits and bleeding per rectum with the majority of patients had more than one symptom at presentation. The distribution of colonic and rectal cancer were nearly equal [48.8% Vs 51.2%]. The most common histopathological type was adenocaroinoma [67.1%] and 46.3% were grade II. Duke's stage C was 40%. The 16 patients presented with metastases, which were categorized as Duke's stage D [19.6%], together with the 12 patients who had unresectable locally advanced tumors were treated by palliative radiotherapy and/or chemotherapy. Nine patients underwent surgical resection only and 21 received postoperative radiotherapy and chemotherapy. The most important prognostic factors were age of patients, stage of disease, histopathologic type and combined treatment modality. The aim of work is analysis of patient characteristics and results of treatment of colorectal carcinoma in 82 patients presented and treated through the period of the study

Results of treatment of low grade gliomas a multivariate analysis

After radiation therapy for 91 cases with low-grade gliomas, 85.7% showed improvement and stabilization of their neurofiunction status, Patients showed radiological response after radiation therapy 87.9%. The overall survival rates were 62% and 20% at two and five years respectively. The factors of prognostic significance were the age, pre-operative tumor size, seizure as initial presenting symptoms histological tumor type, postoperative performance status, extent of surgical excision, radiation field and radiation doses. Postoperative performance status has prognostic impact in favor of patients with Karnofesky scale 100-70%. Oligodendrogliomas have better prognosis than grade I and grade II astrocytomas. Pre-operative tumor size has prognostic impact in favor of patients with tumor size <5cm. Attempts should be carried out in order to do sub-total or gross-total excision of the tumor without increasing neurological deficit. Whole brain irradiation should not be a trend of treatment. Radiation therapy is better to be given to the tumor area detected by CT scan or MRI imaging with 2-3 cm safety margin all around. The aim of this work is multivariate analysis of results of treatment of low-grade gliomas and factors affecting prognosis

Impact of some prognostic factors on breast cancer survival after postoperative adjuvant therapy

Our present study included 206 female breast cancer patients who underwent surgical management followed by postoperative adjuvant therapy. Patients referred to Radiation Oncology Unit, Radiology Department, Tanta University Hospitals during the period between September 1987 through December, 1991 were included in this study. Breast cancer patients [368] represent 41.5% of all female attended and 18.3% of all malignant cases. Of which 206 [23.5%] where studied. All patients were female with a mean age 46.5 [range 21-76 years]. All cases were followed for a minimum period of three years. The factors of prognostic importance were age, menstrual status, tumor size, and axillary nodal involvement on the other hand tumor site and histological types were of non-significant value

Clinico-epidemiological study of primary intracranial neoplasms

One hundred seventy three cases presented with primary intracranial neoplasms were attended and treated at the Radiation Oncology Unit, Radiology Depatment, Tanta University Hospitals, during the period from September 1987 through December 1993 inclusive. They represent 6.3% of all registered cases in this Unit. The collected data for patients including results of clinical data and fundus examinations, operative and biopsy reports together with computed tomography films were reviewed. In this series, 58% were males and 42% were females, with mean age of 34.53 + 20.56 years for whole series. The most common presenting symptoms were headache [69.4%] and vomiting [51.4%] while paresis [24.3%] was the third one. Tinnitus [1.2%] and anosmia [0.6%] were the least presenting symptoms. While 8% of cases were classified as medulloblastoma, 36.4% were classified as astrocytoma, and 6 cases were diagnosed as pineal body tumors [3.4%]

Assessment of radiotherapeutic management of primary brain tumors by computerized tomography and electroence phalography

The results of radiotherapy treatment were evaluated in 38 patients with primary brain tumors [32 gliomas and 6 meningiomas]. During the period from January 1990 to December 1992, 21 males and 17 females with histologically verified brain tumor were attended and received radiotherapy at Oncology Unit, Radiology Department, Tanta University Hospitals. In glioblastomas multiforme and astrocytomas whole brain irradiation was given using two parallel opposed lateral fields to a total dose of 4000-5000 cGy in 4-5 weeks. Localized irradiation was given to the small volume in a boost dose of 1500 to 2500 cGy in 1.5 to 2.5 weeks. For meningiomas the selection of the small localized field was based on tumor size and histology with a total tumor dose of 5000 cGy to 5500 cGy in 5.5 to 6 weeks. Following radiotherapy patients were examined by both computed tomography [CT] and electroencephalography [EEG] which were compared with pre- and postoperative results. After radiotherapy CT evidence of brain tumor response to treatment was not marked. EEG showed marked changes compared to CT

Bladder cancer in the three main age groups

Despite of the fact that the incidence of carcinoma of the urinary bladder associated with bilharziasis that occurs at young age compared to non-bilharzial type, the incidence of this tumor in young adults was not high. On the other hand, over 70- years the incidence was three times greater than below the age of 40 years. A retrospective survey of bladder cancer cases during six years from September 1987 to September 1993 showed 18.2% incidence. The two groups of extreme age were analyzed [below 40 years and 70 years and above] and compared with middle age group. Out of the twenty four cases aged below 40 years [4.8%], only 4 patients [0.8%] was classified histologically as transitional cell carcinoma [T.C.C.]. Out of the 90 patients, presented over 70 years of age [18.1%], 45 showed TCC [9%] on histopathological examination, compared to 35.7% in the middle age group

Postoperative radiotherapy in partial and total cystectomy versus total cystectomy of T1/T2 bladder cancer

We have studied 52 patients with-early bladder cancer [TI/T2] who underwent partial or total cystectomy between January 1987 and December 1992 and this represent about 1% of the total recorded bladder cancer cases. The ten partial and eleven total cystectomy patients received postoperative radiotherapy. The remaining 31 cases underwent radical cystectomy only with no postoperative treatment The mean age of the studied group was 51.3 years. Twenty percent of cases had bladder tumor less than 3 cm while, in 80% it was more than 3 cm in diameter. Squamous cell carcinoma [SCO represented 52% compared to 42 transitional cell carcinoma [TCC] and 6% adenocarcinoma. During the first three years partial cystectomy showed 40% recurrence and 39% of total cystectomy only compared to 27% when postoperative radiotherapy was applied. Grade 3 histology showed 51% and 41% recurrence in SCC and TCC compared to 33% and 25% grade 2 respectively. Distant metastases occurred in 10% of the whole series with nearly equal percentage in the three subgroups. The over all three year survival rate was 75% of the whole series with a higher percentage when total cystectomy was followed with postoperative radiotherapy. There were 4 deaths due to disease and another two fatal surgical complications while there were 3 non-fatal major complications due to surgery and irradiation in the whole series with morbidity rate of 17%