The 1966 outbreak of hemorrhagic fever in Manila

An overall picture of the 1966 outbreak of hemorrhagic fever in Manila is presented. The epidemiological, clinical and pathological aspects of the diseases as observed in the San Lazaro Hospital are described. For a clinical syndrome whose mechanism and pathologic physiology have thus far escaped precise explanation, the author only hopes to share her observations on tha past epidemic. (Summary)

The greater Manila dengue hemorrhagic fever epidemic of 1966

In a study of 408 clinically-diagnosed cases of hemorrhagic fever, from the 1966 Greater Manila epidemic, the largest on record in the Philippines, 217 were confirmed as dengue infections, and 54 strains of dengue virus of three types were recovered. The disease afffected mostly children aged 5 to 14 years, but adults were also significantly involved. Distribution was largely central-urban and outer-urban, with fewer cases in rural areas. Correlation of data for incidence and distribution of positive cases and strains of dengue virus isolated indicated that the epidemic extended from May to October, peaked in July and August, and was caused by dengue type 3. Dengue types 2 and 4 appeared to maintain a low endemic level throughout the period of study. There was no evidence that dengue type 1 or other arboviruses were involved. All cases of hemorrhagic fever with shock, except possibly two, had secondary antibody responses, but no other correlation of antibody response to severity of disease could be made.(Summary)

Choleriform enteritis

1. A brief review of the historical background of the El Tor Vibrio and possible mechanism of action is presented2. 200 cases of Choleriform Enteritis admitted into the San Lazaro Hospital from September 22, 1961 to October 16, 1961 are studied and incidences according to sex, age, immunization and symptomatology are shown3. Pathology and management are also discussed. (Summary)

The treatment of typhoid fever with demethylchlortetracycline and phenylbutazone

1. Twenty five patients with typhoid fever were treated with Ledermycin combined with Butazolidin2. All patients except one recovered. Results were very good in 64 per cent; good in 32 per cent; and unsatisfactory in 4 per cent. In 44 per cent, apyrexia was attained within 24 hours3. With the fall in temperature, symptoms of toxemia disappeared4. The average duration of fever from the start of therapy was 1.8 days5. No case proceeded to hemorrhage or perforation6. There was no diminution in the agglutination titers. No untoward changes in the blood picture were observed. (Summary)