Kinetic methods for the quantitation of triprolidine in bulk and in drug formulations

A kinetic method for the accurate and sensitive determination of triprolidine has been described. The method is based on the alkaline oxidation of triprolidine with KMnO4. At a fixed time of 20 minutes, the formed manganate ion is spectrophotometrically measured at 612 nm. The concentration of triprolidine is calculated using the calibration equation of the fixed time method. The method has been applied successfully to commercial tablet dosage form. The results obtained are compared statistically with those given by the B.P. method. The determination of triprolidine by the fixed-concentration and rate constant methods is feasible with the calibration equations obtained, but the fixed time method proved to be more applicable

Flow inejction amperometric determination of some toxic metals at low levels in aqueous solutions

Copper [II], iron [III], antimony [V] and arsenic [V] were determined as bromine, which is liberated through the reaction of the metal ions with acidic bromide solution by flow injection amperometry at a platinum electrode by injecting the sample into an eluent: KBr in H2SO4 for both Cu [II] and Fe [III], or KBr in HCl for both Sb [V] and As [V]. The rectilinearity range is from 10-3 to 10-7 M. Antimony [III] and arsenic [III], that can be oxidized by bromine, were determined on-line by injecting the acidic solutions of the samples into bromate-bromide eluent and observing the decrease in the bromine signal. The determination was also performed by injecting a pre- reacted solution of bromide and Sb [V] or As [V] and monitoring the bromine produced. The method have been applied successfully to commercial tablet forms [for iron], alloys [for copper] or in the bulk powders [iron, antimony and arsenic]. The results obtained were compared statistically with those given by the titrimetric methods