ABSTRACT
Background: Cirrhosis is the irreversible fibrosis of liver, it continues to be a common cause of morbidity and mortality. It is accompanied by inflammation and malnutrition and thus can have a negative effects on bone metabolism and promote fractures accordingly
Aim of the study: to evaluate the risk of fractures among patients with cirrhosis
Methods: A systematic review of the scientific literature following PRISMA/STROBE guidelines, Medline Cochrane Library and Embase s were retrieved using an algorithm comprising relevant MeSH terms from 1980 to 2017. Publications on the association of cirrhosis/bone fracture were ed independently by the authors and included in both gender and gender-specific meta-analyses, following recalculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies
Results: [st] 8 udies met the inclusion criteria enrolling 988 patients [286 of which are diagnosed with al coholic liver disease [ALD]. Overall, ALD demonstrated a el r ative risk [] RR of 1.825, 95%CI: 1.370 2.28, - < 0.001 P for the development of bone fractures. Bone mineral density [BMD] was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD. Sensitivity analyses showed consistent results
Conclusion: in accordance to the present meta-analysis, there is a significant correlation between bone fractures and ALD independent of BMD
ABSTRACT
Background: A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in many other chronic diseases. Recent studies have suggested a relevance of vitamin D to reproductive physiology. Moreover, recent evidence is establishing to support the hypothesis that vitamin D status may contribute to the development of metabolic disturbances in PCOS
Aim of the study: To investigate the relationship between Vitamin D level and polymorphisms related to metabolic disturbances particularly Insulin resistance in women with PCOS
Methods: A review of the scientific literature [PubMed Search 1960 to 2017] Pubmed, Embase and CENTRAL were searched to identify randomized controlled trials that investigated The Correlation between Depression and Folate Deficiency as the primary outcome. Identification of papers and data extraction were performed by two independent researchers. We searched for relevant trials in the Cochrane Library, MEDLINE [from 1960], Embase [from 1960], and ongoing trial databases; all searches current to October 2017
Results: Eight studies were included enrolling 1225 women; 779 patients with depression and 446 control subjects. Univariate regression analyses of the weighted means indicated a significant correlation between vitamin D and IR predictability in both PCOS and control women. However, the significance was neutralized after factoring BMI in PCOS women
Conclusion: There is a growing body of evidence suggesting an inverse association between vitamin D status and metabolic disturbances in PCOS in the current literature yet heterogeneity of the conducted studies made it difficult to come out with a solid conclusion. Nevertheless, normalization of vitamin D levels is recommended generally and especially for PCOS patients