ABSTRACT
Introduction: Lead [Pb] is a neurotoxin that its different effects on the central nervous system are well-known. Previous studies have reported the potent effects of vitamin C on memory.The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced amnesia
Methods: Male Wistar rats were divided into 4 groups: the control [saline], negative control [lead], positive control [Vitamin C, 150 mg per kg], and experimental [Lead+Vitamin C]. To induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1 month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was tested 24 hours after training
Results: The results showed that lead causes impairment in acquisition and retrieval processes of passive avoidance learning and memory. However, vitamin C administration reinforced passive avoidance learning and memory. All results were significant [P<0.001]
Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial learning and memory