ABSTRACT
To estimate the levels of anti-sperm antibodies in infertile males attending a tertiary care hospital in Karachi. Out of 160 males studied, 132 met the criteria and were included in the study. Semen analysis was done by proper standardized procedures as mentioned in WHO manual for examination of human semen and sperm cervical mucus interaction. A blood sample was drawn to detect the presence of anti-sperm antibodies. Antisperm antibodies were found positive in 8 males suggesting that antisperm antibodies are the etiologic factor causing infertility in 6% infertile male subjects. A positive correlation was found between the ages of patients and antisperm antibodies greater than 70 IU/ml. Direct correlation of circulating antisperm antibodies with male infertility suggests the role of immunologic infertility as an etiologic cause of infertility in idiopathic infertile males of Pakistan