ABSTRACT
The objective of the present study was to determine the plasma Adiponectin concentration in primary school children 6-11 years and to evaluate negative association of Adiponectin in obese children. This cross sectional study was carried out in the Department of Chemistry, Gomal University, Dera Ismail Khan from June 2007 to August 2010. A total number of 1336 primary school children were examined in the Municipality area of Dera Ismail Khan and excluding those suffering from chronic health problems. Height [m], weight [kg] of each child was taken and BMI was calculated according to Quatelet's Index. Body mass Status was also calculated through CDCs' Growth Charts 2002, 2-20years for children to have percentile for each school child. School children with >/= 5[th] percentile were declared normal weight and the ones having >/= 95[th] percentile as obese. 83 school children were randomly selected among 1336 children with 23 [27.71%] normal weight and 60 [72.28%] as obese ones. Gender wise distribution of the sample was 48 [57.83%] boys and 35 [42.16%] as girls. Fasting plasma adiponectin concentration was determined by ELIZA method. Mean plasma adiponectin concentration in normal weight children was noted as 21.38micro g/ml [P = 0.013] and 20.89micro g/ml [P = 0.011] in boys and girls respectively. The observed, mean plasma adiponectin level in obese children was 20.38micro g/ml [P =0.0130] and 25.56micro g/ml [P = 0.0016] in boys and girls respectively. Significant difference in plasma adiponectin concentration was observed between normal weight and obese girls
ABSTRACT
To determine the prevalence of sub clinical hypothyroidism [hyperthyrotropinemia] in obese school children. This cross-sectional study was carried out in Department of Chemistry, Gomal university, Dera Ismail Khan, from June 2007 to August 2010 including eight primary schools of Dera Ismail Khan having mixed population with some of the wards belonging to high socioeconomic group. Thorough clinical examination excluded those suffering from chronic health problems. Height and weight of each child was taken according to standard anthropometric procedures. Body mass index and body mass status of each study subject was calculated according to Quetelet's Index and WHO criteria respectively. a total of 83 school children [6-11 years] were randomly selected among 1336 children. The sample included 23 [27.71%] normal weight children and 60 [72.28%] obese. Gender wise distribution of the sample was 48 [57.83%] boys and 35 [42.16%] girls. Free Thyroxin [FT] and Thyroid Stimulating Hormone [TSH] were measured using radioimmunoassay. Hyperthyrotropinemia was the most commonly observed thyroid hormone dysfunction [8.43%] in the whole sample [n=83] and 8.33% in obese children compared with 3-8% in general population of the United States. Sub clinical hypothyroidism is the most common finding in the childhood obesity. The prevalence of sub clinical hypothyroidism in the present study is 8.43% in the whole sample [n=83] compared with 3-8% in general population of the United States. It is suggested that all the obese children expressing minimum organ abnormalities be investigated to prevent the irreversible problems over the course of many years