ABSTRACT
Objective: To evaluate side effects of Imatinib by patients of chronic myeloid leukemia and their influence on quality of life. Study Design: Descriptive and analytic study. Place and Duration of Study: The study was carried out at department of oncology CMH Rawalpindi, from Jan 2015 to Dec 2015
Material and Methods: The study was carried out at department of oncology CMH Rawalpindi from Jan 2015 to Dec 2015. Patients who had been using Imatinib orally for at least 6 months participated in the study. Patients under 18 years of age were excluded from the study. A questionnaire was developed to record adverse effects. This questionnaire included demographic details and quality of life issues like effects on their mood, daily life activities, work, walking and relationships
Results: Ninety two patients participated in the study. Mean age of the participants was 42.05 years [range 22 to 68 years], 52% were males. Among the study population eighty-seven percent had suffered from at least one adverse reaction. The most commonly complained adverse events were muscle cramps [67 out of 92, 72.8%]; fatigue [58 out of 92 63.04%], gastro intestinal upset [44 out of 92 47.82%] and skin rashes [30 out of 92 32.60%]. More than half of the patients felt that the adverse effect had a negative influence on their daily quality of life
Conclusion: Adverse drug effects were common among CML patients receiving Imatinib therapy. These adverse drug reactions had negative impact on patients' daily life
ABSTRACT
To determine the frequency of dyslipdemias in diabetic patients at Combined Military Hospital Multan. Cross sectional observational. Department of Medicine, Combined Military Hospital Multan from February 2007 to August 2007. Diabetic patients aged between 30-70 years of either gender and having diabetes for >5 years were included in the study. Patients with co-existent hypothyroidism, chronic renal failure, nephritic syndrome, familial hypercholesteremic syndromes, already on lipid lowering drugs, anti-hypertensive drugs, using beta blockers or thiazide diuretics, obese patients with BMI > 30 and those using alcohol were excluded. Blood samples after overnight 10 hours fasting were taken for plasma glucose, serum total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides. Frequency of dylipideamias was analysed using Statistical Package for Social Sciences [SPSS] version 10. Mean age of 200 diabetic patients included in the study was 51 +/- 9.47 years [range 34-70 years] and male to female ratio of 1.21:1. Mean fasting plasma glucose levels of the diabetic patients was 8.2 +/- 2.2 mmol/L. Out of 200 patients, dyslipideamia was present in 163 [81.5%] patients. Hypertrglyceridemia was present in 150[75%] patients, raised LDL-cholesterol in 126 [63%] patients, decreased HDL-cholesterol in 119 [59.9%] patients, and raised levels of total cholesterol in 89 [44.5%] of the patients. Diabetic patients have a high frequency of dyslipidemias especially raised triglycerides, therefore lipid profile is to be checked routinely and its management be given equal importance in addition to glycemic control