ABSTRACT
Objective:To establish an individualized nomogram model to predict the risk of sarcopenia by analyzing the related factors of myopenia in elderly inpatients.Methods:Inpatients in the department of Affiliated Hospital of Qinghai University from January 2017 to December 2018, aged ≥ 60 years old, were included by the diagnostic criteria of Asian sarcopenia working group, and the independent risk factors were screened by logistic regression for the occurrence of sarcopenia. According to the independent risk factors, a nomogram model was established to predict the risk of sarcopenia. Bootstrap method was used to verify the model. C-index and calibration curve were used to evaluate the differentiation and calibration of the prediction model.Results:Totally 83 of 268 elderly patients had sarcopenia, the incidence was 30.9%. Age ( OR = 1.726, 95% CI 1.244-2.432), body mass index ( OR = 0.753, 95% CI 0.621-0.969), current smoking ( OR = 1.081, 95% CI 1.048-3.297), osteoporosis ( OR = 2.031, 95% CI 1.201-4.193) were all independent risk factors of myopenia in elderly patients. The concordance index for predicting the risk of myopenia was 0.775 (95% CI 0.722-0.827). Conclusion:Age, body mass index, osteoporosis, smoking are the independent risk factors of myopenia in elderly patients. The nomogram model can more directly evaluate the risk of sarcopenia in elderly patients.
ABSTRACT
Objective: To study the relationship between plasma level of N-terminal B-type natriuretic peptide (NT-proBNP) and ventricular diastolic dysfunction in elder hypertensive patients without target organ damage. Methods: A total of 66 relevant patients treated in our hospital from 2012-03 to 2014-03 were studied. According to the standard of ventricular diastolic dysfunction, the patients were divided into 2 groups: Study group, n=27 patients with diastolic dysfunction and Control group, n=39 patients without diastolic dysfunction. The patients in Study group were further divided into 3 sub-groups based on Doppler classification of diastolic dysfunction:Grade 1, the patients with E/A90 ms, n=8. Grade 2, the patients with E/A>1.5, DT (150-220) ms, IVRT1.5, DT≤150 ms, IVRT NT-proBNP and ventricular diastolic dysfunction. Results: Plasma level of NT-proBNP was higher in Study group than that in Control group. NT-proBNP level in Grade 3-4 sub-group was obviously higher than those in Grade 1 and Grade 2 sub-groups, NT-proBNP level in Grade 2 sub-group was higher than that in Grade 1 sub-group. Pearson correlation analysis indicated that NT-proBNP level was positively related to systolic blood pressure, diastolic function and E/E’ (r=0.211, P=0.037, r=0.442, P=0.004 and r=0.556, P=0.000), while negatively related to E’/A’ (r=-0.372, P=0.000). Conclusion: The increased plasma level of NT-proBNP are highly support for ventricular diastolic dysfunction in elder hypertensive patients without target organ damage, NT-proBNP level is related to ventricular diastolic function.