ABSTRACT
Objective: To investigate the association of mixed exposure to greenness and nitrogen dioxide(NO2) and hypertension among the older adults aged 65 years and over in China. Methods: The study subjects were from the Chinese Longitudinal Healthy Longevity Survey from 2017 to 2018. A total of 15 423 older adults aged 65 years and over meeting the criteria were finally included in the study. A questionnaire survey was used to collect information on demographic characteristics, lifestyle habits and self-reported prevalence of hypertension. Blood pressure values were obtained through physical examination. The level of normalized difference vegetation index(NDVI) was measured by the Medium-resolution Imaging Spectral Radiator(MODIS) of the National Aeronautics and Space Administration(NASA). The concentration of NO2 was from China's surface air pollutant data set. Meteorological data was from NASA MERRA-2. The exposure to NDVI and NO2 for each study subject was calculated based on the area within a 1 km radius around their residence. The association between mixed exposure of NDVI and NO2 as well as their interaction and hypertension in older adults was analyzed by using the multivariate logistic regression model. The restrictive cubic spline(RCS) function was used to explore the exposure-response relationship between greenness and NO2 and the risk of hypertension in study subjects. Results: The mean age of 15 423 older adults were (85.6±11.6). Women accounted for 56.3%(8 685/15 423) and 55.6%(8 578/15 423) lived in urban areas. The mean time of residence was (60.9±28.5) years. 59.8% of participants were with hypertension. The mean NDVI level was 0.41±0.13, and the mean NO2 concentration was (32.18±10.36) μg/cm3. The results of multivariate logistic regression analysis showed that NDVI was inversely and linearly associated with the hypertension in older adults, with the OR(95%CI) value of 0.959(0.928-0.992). Compared with the T1 group of NDVI, the risk of hypertension was lower in the T3 group, with the OR(95%CI) value of 0.852(0.769-0.944), and the trend test was statistically significant(P<0.05). Compared with the T1 group of NO2, the risk of hypertension was higher in the T2 and T3 groups, with OR(95%CI) values of 1.160(1.055-1.275) and 1.244(1.111-1.393), and the trend test was statistically significant (P<0.05). The result of the RCS showed that NDVI was inversely and linearly associated with hypertension in older adults. NO2 was nonlinearly associated with hypertension in older adults. The interaction analysis showed that NDVI and NO2 had a negative multiplicative interaction on the risk of hypertension, with OR(95%CI) value of 0.995(0.992-0.997). Conclusion: Exposure to greenness and NO2 are associated with hypertension in older adults.
Subject(s)
Aged , Humans , Female , Nitrogen Dioxide , Air Pollution , Prevalence , Hypertension/epidemiology , China/epidemiology , Particulate Matter/analysisABSTRACT
Objective: To investigate the association of plasma vitamin B12 level with plasma uric acid level among the elderly over 65 in 9 longevity areas of China. Methods: The elderly over 65 years old with complete information on plasma vitamin B12 and plasma uric acid from Healthy Aging and Biomarkers Cohort Study (2017 to 2018) were recruited in this study. Information on socio-demographic characteristics, life styles, diet intake, and health status were collected by questionnaire and physical examination; and fasting venous blood was collected to detect the levels of plasma vitamin B12, uric acid and other indicators. Multiple linear regression models were used to analyze the association of plasma vitamin B12 level per interquartile range increase with plasma uric acid level. The association trend of plasma vitamin B12 level with plasma uric acid level was described by restrictive cubic splines fitting multiple linear regression model. Multiple logistic regression models were used to analyze the association of plasma vitamin B12 level stratified by quartiles with hyperuricemia. Results: A total of 2 471 participants were finally included in the study, the age was (84.88±19.76) years old, of which 1 291 (52.25%) were female. The M (Q1, Q3) level of plasma vitamin B12 was 294 (203, 440) pg/ml and the plasma uric acid level was (341.01±90.46) μmol/L. A total of 422 participants (17.08%) were defined with hyperuricemia. The results of multiple linear regression model showed that there was a positive association of plasma vitamin B12 level with plasma uric acid level after adjustment for covariates (P<0.05). An IQR increase in plasma vitamin B12 (237 pg/ml) was associated with a 6.36 (95%CI: 2.00-10.72) μmol/L increase in the plasma uric acid level. The restrictive cubic splines curve showed a positive linear association of log-transformed plasma vitamin B12 with uric acid level (P<0.001). Conclusion: There is a positive association of plasma vitamin B12 level with plasma uric acid level among the elderly over 65 years old in 9 longevity areas of China.
Subject(s)
Humans , Female , Aged , Aged, 80 and over , Male , Vitamin B 12 , Uric Acid , Cohort Studies , Hyperuricemia , Vitamins , Folic AcidABSTRACT
Objective To analyze clinical effect of quinolones combined with refining nursing of prevention postoperative infection of chronic appendicitis. Methods 100 cases of chronic appendicitis in our hospital were selected as the study object. 100 cases were randomly divided into two groups, experimental group and control group, 50 cases in each group. The control group was given quinolones, the experimental group were refined nursing, diet intervention, patience for patients to explain the operation knowledge on the basis of the control group.The clinical efficacy and infection of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment,the effective rate was 92.0% in the experimental group and 76.0% in the control group.The difference between the two groups was statistically significant(P<0.05). In the control group, the number of infection cases was 6, and the number of incision infection in the experimental group was 2 cases, with statistical difference(P<0.05). Conclusion Quinolones combined with refining nursing can get ideal clinical efficacy in the prevention of chronic appendicitis postoperative infection, can significantly reduce the occurrence probability of infection, improve the quality of life.
ABSTRACT
Objective To analyze clinical effect of quinolones combined with refining nursing of prevention postoperative infection of chronic appendicitis. Methods 100 cases of chronic appendicitis in our hospital were selected as the study object. 100 cases were randomly divided into two groups, experimental group and control group, 50 cases in each group. The control group was given quinolones, the experimental group were refined nursing, diet intervention, patience for patients to explain the operation knowledge on the basis of the control group.The clinical efficacy and infection of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment,the effective rate was 92.0% in the experimental group and 76.0% in the control group.The difference between the two groups was statistically significant(P<0.05). In the control group, the number of infection cases was 6, and the number of incision infection in the experimental group was 2 cases, with statistical difference(P<0.05). Conclusion Quinolones combined with refining nursing can get ideal clinical efficacy in the prevention of chronic appendicitis postoperative infection, can significantly reduce the occurrence probability of infection, improve the quality of life.