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Objective: To explore the effect of clinical pharmacists participating in the clinical pharmacy work in neurosurgery de-partment and the influence on the rational drug use index. Methods: A retrospective analysis on the monthly drug proportion, antibac-terial drug utilization rate and intensity, and the other indicators before and after the intervention performed by clinical pharmacists in neurosurgery department was carried out, and the consumption sum, DDDs and medical records were statistically analyzed in April and June 2017. Results: After the intervention, the proportion of medicine, hospital days per capita, use rate and intensity of antimicrobial drugs, and the other rational drug use indices were significantly improved in neurosurgery department, and the differences in the indi-ces before and after the intervention were significant (P<0. 01). Conclusion: Consultation practice of clinical pharmacists in neuro-surgery department can effectively assist and guide the clinical treatment and improve the level of rational drug use.
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Objective:To discuss the causes and characteristics of drug-related problems(DRPs) of antiepileptic drugs by the in-vestigation of antiepileptic drugs' use in our hospital in order to provide reference for the rational clinical application of antiepileptic drugs. Methods:A retrospective analysis on 878 inpatients' records including antiepileptic drug application in our hospital from Janu-ary to December 2016 was carried out. The gender,age,etiology,application of antiepileptic drugs,usage,combination and adverse reactions were statistically analyzed in order to analyze the epidemiological characteristics of antiepileptic drugs in our hospital. At the same time,the necessity,safety and validity of the DRPs of antiepileptic drugs were studied by the international generic Spanish drug related research method(Granada-Ⅱclassification method). Results:Among the 878 cases,most were male patients(60.71%) and the proportion of patients over 50 years old was 69.02%. Patients with cerebrovascular diseases accounted for the most (323 cases, 36.79%),and 7 varieties of antiepileptic drugs were involved, and sodium valproate was with the largest proportion (489 cases, 51.75%). The DRPs were classified as DRP2(49 cases),DRP5(22 cases) and DRP6(8 cases). Conclusion:In view of the epi-demiological characteristics of antiepileptic drugs and DRPs specific issues in clinical applications, clinical pharmacists need to strengthen the intervention in DRPs of antiepileptic drugs in order to promote the safety and reasonability of clinical application.
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Objective:To analyze the refused payment in medical insurance drugs in our hospital in 2016 to promote the rational drug use.Methods:The refused payment in medical insurance drugs was analyzed , the reasons were summarized and the medication rationality was analyzed as well .Results:There were 372 cases of refused payment in medical insurance drugs in 2016 , and among them, 281 cases were with excessive medication accounting for 75.54％.There were 46 cases of off-label drug use, which accounted for 54.33％in the whole refused sum.The other reasons for the refused payment in medical insurance drugs included contraindication use of medication and violation of ladder medication etc .Conclusion:In the diagnosis and treatment process , doctors should be famil-iar with and follow the medical insurance payment system .The current health insurance payment system also requires a combination of medical technology , pharmacy economics and Chinese patient data .Medicare payment system needs to be improved by information technology.At the same time, pharmacists should play active role , and medical institutions should be encouraged to take effective measures to promote clinical rational drug use , which can promote the maximum normative treatment for each patient .
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Objective To summarize the method and experience of pharmaceutical care for a patient with insulin resistant. Methods The rationality of the treatment plan was analyzed by the clinical pharmacist, and the entire pharmaceutical care process was implemented to the patient. Results Doctors took the advice of clinical pharmacists, perfected the treatment plan. The treatment was safe and effective. The patient was discharged with a better health condition. Conclusion Clinical pharmacist integrates in the treatment team,and to promote the rational use of drugs.
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Compared with traditional oral administration and parenteral administration, transdermal administration has such fea-tures as convenient application, high local drug concentration and strong security. This paper reviewed the composition, characteristics and applications of new carriers ( microemulsions, ethosomes, transfersomes, niosomes, proliposomes, gels and so on) in transdermal drug delivery system with increased drug transdermal transport efficiency in recent years. The advantages of the new transdermal drug delivery carriers make them possess high research value and broad development space.
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Plumbagin [PLB] isolated from Plumbago zeylanica L [Plumbaginaceae] was evaluated for the suppressive effect and mechanism on ADP induced rat platelet aggregation. Adult male SD rats were randomly divided into control group, clopidogrel group, PLB 25mg/kg group and PLB 50mg/kg group. Clopidogrel [13.5mg/kg per day] and PLB [25 and 50mg/kg per day] were orally given to experimental rats by gavage for seven consecutive days. The antiplatelet properties were assessed by measuring the ADP-induced platelet aggregation rate [Agg[max]]. The level of cAMP in platelets before aggregation was determined by ELISA. The protein expression of pAkt, Akt, pPLC beta 3 and PLC beta 3 in platelets was measured by western blot. Our data indicated that PLB [25 and 50mg/kg] significantly inhibited ADPinduced rat platelet aggregation as well as clopidogrel [13.5mg/kg] in a dose dependent manner compared with the control group. PLB [25 and 50mg/kg] remarkably reduced the ADP-induced PLC beta 3 phosphorylation but not Akt in platelets as compared with the control group. The present study suggests that PLB exerts a suppressive effect on ADPinduced rat platelet aggregation, at least in part, through P2Y[1]-PLC signaling pathway
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Objective:To understand the situation of time limitation prescriptions of outpatients in our hospital. Methods:A ret-rospective study was conducted on 1 107 time limitation prescriptions from July 1st to 31th in 2015. Results: There were 1 107 time limitation prescriptions in 16 063 prescriptions (6. 89%), which included 902 patients, and among them, there were more than one time limitation prescription in one day for one patient. As the increase of age, the number of patients with time limitation prescriptions was increased. The number of time limitation prescriptions with the sum between 101 and 200 yuan was the most (34. 51%). The di-agnosis of top 10 of the drugs according to the doctor’ s advice and the actual top ten was substantially consistent, and among them, half were Chinese patent medicines. Conclusion:Time limitation prescriptions are the products of medical insurance policy. The man-agement of time limitation prescriptions can’ t be only defined as the quantity superposition of drugs, and it is necessary to generate in-dividualized strategy according to the properties of diseases, drugs and patients in order to obtain more reasonable management strate-gies, and the ultimate purposes are benefiting patients and obtaining more rational distribution of medical resource.
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Dipeptidyl peptidase-4 (DPP-4) inhibitors, a new kind of oral hypoglycemic drugs, can significantly lower blood glu-cose levels in the patients with type 2 diabetes without common side effects such as body weight gain, hypoglycemia and gastrointestinal disturbances. Therefore, DPP-4 inhibitors play an increasingly important role in the treatment of type 2 diabetes. In this review, the re-search progress in the action mechanism, pharmacokinetics and clinical applications of DPP-4 inhibitors was summarized in order to provide reference for the clinical application.