ABSTRACT
Objective To study the effect of atorvastatin combained with ligustarazine on incidence of postoperative Atrial fibrillation(AF) after percutaneous coronary intervention and discuss the changes of inflammatory factors.Methods Ninety ACS patients were divided into three groups at random:25 cases of atorvastatin combined with iigustarazine treatment group (Group A),30 cases of Atorvastatin treatment group (Group B) and 68 cases of a control group (Group C).All of the patients were treated by PCI.The incidence of AF was observed during 2 weeks after PCI.The densities of high sensitivity C-reactive protein (hs-CRP)and metal proteinase-9 (MMP-9)in blood were examined after PCI for 72 hours.The changes of hepatic and renal functions were observed.Results ①The incidence of postoperative AF in group A was lower compared with group B (P=0.023) and C (P=0.028) ; there were no significant differences between group B and C.The levels of serum hs-CRP and MMP-9 in group A and group B were significantly decreased after PCI for 72 hours and large dose was more significant (P=0.031).②Tnere were no significant differences of hepatic and renal function among the three groups.Conclusion Atorvastatin combained with ligustarazine treatment before PCI may decrease the incidence of postoperative AF.The densities of serum hs-CRP and MMP-9 were decreased after the treatment of atorvastatin and large dose was more significant.
ABSTRACT
Objective:To observe the efficacy of Firebird drug-eluting stent in patients with type 2 diabetes and coronary heart disease. Method:90 patients with type 2 diabetes and coronary heart disease from March 2005 to December 2006 were enrolled to have the treatment of percutaneous coronary invention,47 in Domestic Firebird Stent group and 43 in Bare Stent group. All patients were administered asprin and Clopidogrel regularly before and after procedures,meanwhile, medical treatment was used strongly and strictly. Followed up the patients after PCI,observed the major adverse cardiac events(MACE),and compared the efficacy between the two groups. Results:Coronary angiographic(CAG) showed that the patients with more than 2 lesion coronaries take 71.11 % of all.74 Firebird Stents were implanted in Firebird group and 55 Bare Stents were implanted in Bare metal stents group.Each patient has got an successful operation. Mean follow-up duration was 10.2?3.3 months after stent implanting. 3 patients suffered angina pectoris reoccurrence and 2 suffered major adverse cardiac events(MACE) in Firebird Stent group,while 13 patients suffered angina pectoris reoccurrence and 13 suffered MACE in Bare metal stent group. Rate of angina pectoris reoccurrence and MACE occurrence in Firebird Stent group were much lower than that of in Bare metal stent group,there was significant difference between the two groups(6.4% vs 30.2%,P0.05). Conclusion:Firebird stent in patients with type 2 diabetes and coronary heart disease has a definite clinical efficacy,which can reduce the occurrence of MACEs.