ABSTRACT
Objective To explore the correlation between diabetic retinopathy (DR)and glycosylated blood protein(HbA1c) among diabetic patients aged 80 years and over.Methods The medical records of 403 diabetic patients(≥80 years old)admitted to endocrine department of Heji Hospital Affilicated to Changzhi Medical College from January 2013 to March 2017 were retrospectively analyzed.They were divided to three groups of non-DR group (254 cases),non proliferative DR group (122 cases) and proliferative DR group (27 cases).The duration of diabetes,levels of fasting blood glucose and glycosylated hemoglobin were compared among groups.Results One-hundred and forty-nine(37.0％)elderly diabetic patients developed DR.DR was associated with longer history of diabetes and hypertension and with family history of diabetes.There were statistically significant differences in serum levels of fasting blood glucose and glycosylated hemoglobin(both P＜ 0.05)among three groups.Furthermore,multivariate analysis showed that glycosylated hemoglobin was associated with the incidence and development of DR(OR =4.137,P＜0.01).Conclusions More than one third(37.0 ％) elderly diabetic patients(≥80 years old) have diabetic retinopathy,which is associated with the level of glycosylated hemoglobin.
ABSTRACT
Objective To explore the correlation between diabetic retinopathy (DR)and glycosylated blood protein(HbA1c) among diabetic patients aged 80 years and over.Methods The medical records of 403 diabetic patients(≥80 years old)admitted to endocrine department of Heji Hospital Affilicated to Changzhi Medical College from January 2013 to March 2017 were retrospectively analyzed.They were divided to three groups of non-DR group (254 cases),non proliferative DR group (122 cases) and proliferative DR group (27 cases).The duration of diabetes,levels of fasting blood glucose and glycosylated hemoglobin were compared among groups.Results One-hundred and forty-nine(37.0％)elderly diabetic patients developed DR.DR was associated with longer history of diabetes and hypertension and with family history of diabetes.There were statistically significant differences in serum levels of fasting blood glucose and glycosylated hemoglobin(both P＜ 0.05)among three groups.Furthermore,multivariate analysis showed that glycosylated hemoglobin was associated with the incidence and development of DR(OR =4.137,P＜0.01).Conclusions More than one third(37.0 ％) elderly diabetic patients(≥80 years old) have diabetic retinopathy,which is associated with the level of glycosylated hemoglobin.