Analgesic, Anti-inflammatory and neuropharmacological effects of Atropa belladonna

The present study was carried out to investigate, in vivo, analgesic, anti-inflammatory and neuropharmacological activities of the methanolic extract of Atropa belladonna. The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuro-pharmacological activities were evaluated by open field, rearing test, cage cross, swim test, head dip and traction tests. The anti-inflammatory activity was assessed by formalin induce inflammation on hind paw. The extract showed highly significant [p<0.001] analgesic activity with % inhibitions of writhing response at doses 100 and 300mg/kg body weight were 28.5% and 57.1%, respectively. The extract at both doses showed significant [p<0.05] sedative effect in-cage cross test and highly significance value [p<0.001] in high dose. In-open field test, the extract showed significant [P<0.05] anxiolytic activity at higher dose whereas in rearing test activity shows significant p-value at both doses. The extract also showed significant value for anti-inflammatory activity. The findings of the study clearly indicated the presence of significant analgesic, neuro-pharmacological and anti-inflammatory properties of the plant, which demands further investigation including, compounds isolation

Biochemical analysis of the crude extract of Momordica charantia [L.]

Momordica charantia [L.] commonly referred as bitter gourd, karela and balsam pear. Its fruit is used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. The study was conducted to find out the biochemical aspects of crude extract of whole fruit of M. charantia including seeds which includes blood test [Hemoglobin, RBC, Total leukocyte count, platelets count, HbA1C [Glycocylated heamoglobin Type A1C]], Lipid profile test and electrolyte balance. Hemoglobin [7.1 +/- 0.14], platelets count [827 ×10[9] +/- 1.95], Cholesterol level [111 +/- 2], HDL [high density lipoproteins] [20 +/- 1.22] at 10mg shows marked increase in values as compared to control. While 25 mg dose shows insignificant result. Electrolyte balance are found significant at 10mg and 25mg except bicarbonates [Na[+]=143 +/- 1.87, K[-]=3.45 +/- 0.35, Cl[-] =108 +/- 1.48]. Another important property of M. charantia is the elevation of platelet counts, heamoglobin and specifically high-density lipoproteins [HDL]. It also controls cholesterol, triglycerides, HDL, LDL and VLDL at low dosage [10mg]. Further studies can be conducted to find out which phytochemical components acts on specific biochemical activity