ABSTRACT
In many previous studies, green tea has been shown to prevent and treat type 2 diabetes 16-18. Some controversial results have also been noticed in few studies. Primary objective of the present study was to determine the effect of green tea polyphenols on glycaemic control among the patient with type 2 diabetes. Conflicting data exists according to previous studies about green tea that it might have a positive effect on the glycaemic control in patients with diabetes mellitus type 2. The aim of the present study was to give evidence whether a crude extract of green tea improves glycated haemoglobin A1C [HbA1C] and fasting plasma glucose in patients with type 2 diabetes. Study was prospective, interventional and randomized. This study was conducted at the Department of IMBB [Molecular Biology], University of Lahore from April 2007 to June 2007. A total of 60 patients, 20 with diagnosed diabetes mellitus type 2 taking oral anti-diabetics and 20 diabetic individuals who were not taking any hypoglycemic drug, of either sex were randomly assigned to take green tea extract twice a day, at the dose of 15 gram, for 3 months. A group of 20 healthy subjects was also enrolled in the study. A very significant difference between the pre- and post-intervention fasting plasma glucose level was observed in both the groups of diabetic patients while no significant difference was seen regarding HbA1C level. Significant changes were not observed in either of the parameters in healthy individuals, as was expected throughout the study. No adverse effects were observed in any of the three groups. The green tea extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control
ABSTRACT
The present work was undertaken to analyze qualitatively the serum electrolyte [K[+], Na[+], Mg[2+], PO4[-3] and Cl[-]] levels by photometric analysis in cancer patients as compared to non-cancer individuals. An understanding of the mechanisms involved in disease pathogenesis is paramount for prevention and treatment in cancer patients. Total 120 blood samples were collected for analysis randomly which were divided into two groups as A [leukemia patients] and B [normal individuals] having 60 in each. Both of these groups were further sub-divided [20 each] into three age groups [20-35, 36-50 and 51-70] A1, B1, A2, B2, A3, B3 respectively. A significant [p<0.05] increase in serum K[+] level [hyperkalemia] was observed in cancer patients as compared to normal individuals having a non significant [P>0.05] interaction with the age limits. However a significant decrease [P<0.05] in the levels of Mg[2+], PO4[-3] and Cl[-] [hypomagnesia, h pophosphatemia and hypochloridemia respectively] was recorded in group B as compared to group A having independency of age limits. Low serum Na[+] [hyponatremia] was observed in Group B3 as compared to Group A3 [51-70] except the age limits [20-35 and 36- 50] which showed a non significant interaction with this decreased level of sodium. The data was statistically analyzed by ANOVA and a highly significant [P< 0.05] difference was obtained between both of the groups