ABSTRACT
Nowadays brain tumors remain as a significant cause of morbidity and mortality and are often treatment refractory. The grading of brain tumor has an important implication in clinical management. Currently, magnetic resonance spectroscopy [MRS] is an important modality in evaluating and grading brain tumors. The aim of this study is evaluation of metabolites in the differentiation of brain tumors and grading of brain gliomas using HMRS [proton magnetic resonance spectroscopy].The studies were performed using single voxel MRS ¡3Tesla with pulse of sequence used for MRS was point resolved single volume spectroscopy [PRESS]with repetition time [TR] 1000-6000ms and echo time [TE] 36-136ms and The detected distinguished metabolites was included Choline [Cho], Creatin [Cr], and N-acetyl a aspartate [NAA], 37cases had data which passed quality control. The Patient ages ranged from 7 To 81 years, 17 were male and 20 female.MRS data was processed using SYNGO software to give mean spectra and metabolite concentrations which were compared using min it a band SPSS. To test the primary hypothesis, univariate logistic regression was performed on each individual measured metabolite quantity. Significant differences were found in concentrations of key metabolites and Cho/NAA and Cho/Cr ratios using T-test and significance [P