ABSTRACT
Background: Mutations in the coding region of the Chemokine Receptor 5 [CCR5] genes reduce or eliminate CCR5 expression in immune cells and progression of HCV infection. This study aimed to investigate the role of this mutation in HCV infection in Iranian patients in comparison with healthy individuals
Methods: 100 HCV infected patients and 100 healthy individuals were randomly selected. The CCR5-DELTA32 genotypes were determined using specific primers and PCR method
Results: The agarose gel electrophoresis showed a189-bp fragment from wild type for both alleles of CCR5 gene. The CCR5-DELTA32 allele was not found in any HCV infected and healthy subjects
Conclusion: The mutation in CCR5 gene was not detected in any of the two groups; therefore, the role of CCR5 gene expression in immune cells and progression of HCV infection needs to be studied in larger samples in our country
ABSTRACT
Background: dermatomycoses are a major public health problem. Tinea cruris is a form of Dermatomycoses. Tinea cruris is a common infection in the groin area, genitals, pubic area, perineum and perianal skin.The purpose of thisstudywas to investigate the cutaneous fungal infections among students in a school dormitory
Materials and Methods: the study was performed on 110 male students dormitory aged between 18 to 28 years.From the specimens obtained; direct preparations were made using %10 potassium hydroxide and cultured on sabouraud dextrose agar containing 0.05 mg/ml chloramphenicoland 0.5 mg/ml cycloheximide [Scc]. Identification of fungi was performed according to morphologic and microscopic growth of the colonies and using slide culture method
Results: 17 people out of 110 individuals were diagnosed with cutaneous fungal infections. Six people were diagnosed with dermatophytosis. All cases of dermatophytosis were Tinea cruris. Epidermophyton floccosum, the anthropophilic species, was only isolated dermatophyte.The prevalence of Tinea cruris was 5.5% and the Prevalence of Pityriasis versicolor was 4.5%
Conclusion: the most important source of transmission of anthropophilic dermatophyte species was by men to men.The results of this study is similar to most other studies in Iran and other countries. In addition to treatment, other necessary steps should be applied in order to prevent infection and reduce the risk of pathogens