ABSTRACT
To determine the effects of herbal drugs in Hypercholesterolemia, Experimental Study, This study was conducted in the Department of Pharmacology, University of Karachi from Jan. 2007 to Dec, 2008. In the present study experiments regarding lipid profile were performed on rabbits of either sex, the calculated dose was administered for 30 days and 60 days [High dose and low dose group], Alfagin possess wide therapeutic range and is comparatively safe, animals of neither group showed no gross toxicity, No death occurred in control and test animals, Alfagin has been shown having, lowering capability of cholesterol. It has been concluded that Alfagin is beneficial in hypercholesterolemia
ABSTRACT
Topical cortlcosteroids are used in different skin conditions. The objective of this study is to assess the efficacy of hydrocortisone in treatment of lichen simplex chronicus, which Is ignored in our population. Forty male and forty female patients suffering from lichen simplex chronicus affecting different parts of the body as nape of the neck, arms, back of the legs and ankle were advised to apply hydrocortisone cream three times a day for four weeks. They were followed up weekly for four weeks. Pruritus and lichenification were scored at 4-grade scale i.e. none, slight, moderate and severe at base line and on each follow up visit. Significant improvement in pruritus was noticed in all groups except Group A2 the results were non significant. Regarding lichenification significant results were observed only in three group [A2, B1, B2] others remained non significant. Assessment shows that hydro-cortisone cream is effective antipruritic and has mostly nonsignificant effect on lichenification
ABSTRACT
Entoban is a well balanced composition of medicinal herbs which includes Holarrhena antidysenterica, Berberis aristata, Aegle marmelos, Quercus infectoria, Butea Frondosa and Myrtus Communis. It is used in amoebic dysentery. The study was carried out on 27 healthy white rabbits of either sex weighing from 1800 to 2000 grams. All animals were equally divided into three groups one served as control, the other two received normal and high doses of entoban syrup. Before administration of the drug animals were acclimatized to housing conditions for 15 days. Entoban was administered in normal dose 1.14 mg / kg and 2.29 mg / kg high dose for a period of 60 days. The control group received normal saline equivalent to the volume of respective doses according to their body weight. Blood samples of about 7cc were collected from the animals through cardiac puncture various biochemical tests were done to consider cardiac, renal and hepatic parameters were done. Cardiac, renal and hepatic parameters were found to be in normal range with high dose. It de-termines that entoban is a safe drug. Therefore cardiac, renal, and hepatic toxicity has been ruled out. Entoban can be safely administered for amoebic dysentery because it does not affect the heart, liver and kidneys
ABSTRACT
Doxorubicin an anthracycline antibiotic and antitumour agent is one of the highly effective antineoplastic drug for the treatment of several different human cancers. The clinical use of this drug is limited by its cardiotoxicity including dose related arrhythmias and often irreversible add from discussion cardiomyopathy. The inotropic and chronotropic activity of different doses of doxorubicin was first evaluated and after determining the fixed effective dose of doxorubicin, the beta receptor activity of doxorubicin was evaluated. The effect of propranolol on heart in presence of doxorubicin was evaluated. Thirty male rabbits weighing 1000 - 1500 grams were used. Drugs used were Doxorubicin and Propranolol. The actions of drugs were studied on the isolated heart of these animals. Krebs ringer buffered physiological solution was prepared and used. To perform the experiment complete set of Lagendroff's apparatus was used. Recording was done on graph paper. Other accessories used were isometric transducer, thermostat oxygen, one ml graduated insulin syringe [to inject the test samples]. Pate of contraction of heart and amplitude of contraction was measured [in centimeters] from baseline. Results were calculated statistically on S.P.S.S. We have evaluated the physiological interactions of Doxourbicin with Adrenaline [agonist] in the first part of the study and in this study the interaction with antagonist [Propranolol] has been studied to evaluate the effects leading to up or down regulation of b receptors