ABSTRACT
lnterleukin-8 [IL-8] is produced within the urinary tract during urosepsis and is involved in the recruitment of neutrophils to the urinary compartment, in addition, deliberate colonization of the human urinary tract with E.coli resulted in a rapid increase in urine IL-8 levels without a detectable rise in IL-8 in serum. This study was conducted in Mansoura University Children's Hospital, and comprised 56 children with febrile urinary tract infection [UTI] and 10 matched healthy controls. Urine samples were taken from patients and control subjects and were analyzed by microscopic examination and bacterial culture. Urinary IL-8 measurements were performed for all samples. A significant increase in urinary IL-8 level was recorded in patients with febrile urinary tract infection compared to healthy controls [P<0.001]. The highest median urinary IL-8 level was found in febrile UTI with E.Coli, followed by staphylococcal infection. In conclusion, urinary IL-8 level may help in the diagnosis, and follow up of children with febrile UTIs