ABSTRACT
Our objective was to study the effect of dorzolamide on corneal hydration in an 18-week controlled experiment using ultrasonic pachymetry. Twenty-eight male rabbits were divided randomly into four groups. The 7 rabbits in each group received eye drops containing either 2 percent (w/v) dorzolamide or placebo in their right eye, or in their left eye. The 2 percent dorzolamide rabbits were treated every 8 h. Fellow eyes are defined as eyes which did not receive either dorzolamide or placebo. The study was blind for both the person who applied the drug and the one who performed the pachymetry. The effect of treatments is reported on the basis of the percentage of pachymetric variation compared to the measurement made before drug application. There was no significant difference (P = 0.061) in pachymetric variation between dorzolamide (-4.42 ± 11.71 percent) and placebo (2.48 ± 9.63 percent). However, there was a significant difference (P = 0.0034) in pachymetric variation between the dorzolamide fellow eyes (-7.56 ± 10.50 percent) and the placebo (-4.42 ± 11.71 percent). In conclusion, dorzolamide did not increase the corneal thickness in rabbits.
Subject(s)
Animals , Male , Rabbits , Carbonic Anhydrase Inhibitors/pharmacology , Cornea/drug effects , Sulfonamides/pharmacology , Thiophenes/pharmacology , Administration, Topical , Carbonic Anhydrase Inhibitors/administration & dosage , Cornea , Random Allocation , Sulfonamides/administration & dosage , Thiophenes/administration & dosageABSTRACT
Utilizando-se de medidas de intervalos anatomicos do olho e fenda palpebral, os autores analisam a magnitude dos erros experimentais cometidos na obtencao das mesmas e propoe um metodo de avaliacao da pericia do leitor escolhido para tais mensuracoes
Subject(s)
Eye , Weights and MeasuresABSTRACT
Um estudo comparativo das medidas da posicao ocular obtidas com os metodos de Hirschberg e de Krimsky foi feito em 50 olhos de pacientes estrabicos submetidos a anestesia geral. Conclui-se que, tolerando-se pequenas diferencas, as leituras fornecidas pelos dois metodos sao equivalentes