ABSTRACT
To study the effect of tribulus terristris on urinary pH, uric acid and calcium as a herbal diuretic agent. Descriptive study. The study was conducted postgraduate medical institute [PGMI] Lahore and duration of study was two weeks. Tribulus terristris extract [100 mg/kg body weight] was administered in rabbits. Rabbits are divided into two groups CT and Tt. There were significant alkalinization of urine and significant reduction in urinary uric acid level and insignificant urinary calcium level observed. It is concluded that alkalinization and reduction of urinary uric acid by Tt would be helpful to reduce renal stone formation
ABSTRACT
We have observed the effects of aspirin and propranolol on the adrenaline-stimulated activity of the isolated auricles of the rabbit heart as well as on the ischaemia-induced and reperfusion-induced activity of the pentobarbitone-anesthetized rabbit heart. Aspirin [25-100 uM] has suppressant effects on the adrenaline-stimulated tachyarrhythmias of the isolated auricles. Aspirin [12.5 mg/kg] also suppresses ischaemia-induced and reperfusion induced tachycardia. These effects of aspirin are similar to propranolol [5x10[-8] M - 3x10[-6] M for isolated auricles and 0.02 mg/kg for pentobarbitone-anesthetized rabbits]. Aspirin-propranolol combination showed no significant effects on the isolated auricles of the rabbit heart while ischaemia-induced and reperfusion induced tachyarrhythmias are significantly suppressed. Therefore, we conclude that aspirin and propranolol alone have marked suppressant effects on the adrenaline-stimulated activity of isolated auricles while aspirin-propranolol combination has no such effect. On the other hand, low dose of aspirin and propranolol have significant suppressant effects on the ischaemia-induced and reperfusion-induced tachyarrhythmias and the combination of aspirin and propranolol showed potentiation in this type of tachyarrhythmias