Association between serum total testosterone and body mass index in middle aged healthy men

To determine correlation of serum total testosterone with body mass index [BMI] and waist hip ratio [WHR] in healthy adult males. A cross sectional study was conducted on 200 nonsmoker healthy males [aged 30-50 years] university employees. They were selected by convenience sampling technique after a detailed medical history and clinical examination including BMI and Waist Hip Ratio [WHR] calculation. Blood sampling was carried out to measure serum total testosterone [TT] using facilities of Chemiluminescence assay [CLIA] technique in Dow Chemical Laboratory. Independent sample T test was used for mean comparisons of BMI and WHR in between low and normal testosterone groups. [Subjects having < 9.7 nmol/L of total testosterone in blood were placed in low testosterone group and subjects having = 9.7 nmol/L of total testosterone in blood were placed in normal testosterone group]. Correlation of testosterone with BMI and WHR was analyzed by Pearson Correlation. Mean [ +/- SD] age of the subjects included in this study was 38.7 [ +/- 6.563] years mean [ +/- SD] total testosterone was 15.92 [ +/- 6.322]nmol/L. The mean [ +/- SD] BMI, and WHR were 24.95 [ +/- 3.828] kg/m[2] and 0.946 [ +/- 0.0474] respectively. Statistically significant differences were observed in the mean values of BMI and WHR for the two groups of testosterone. Significant inverse correlation of serum total testosterone with BMI[r = -0.311, p = 0.000] was recorded in this study. However testosterone was not significantly correlated with waist/hip ratio. [r = -0.126, p = 0.076] Middle age men working at DUHS who have low level of serum total testosterone are more obese than individuals with normal total testosterone level

Relationship of testosterone with hemoglobin in healthy fertile males

To establish a probable relationship of serum total testosterone with hemoglobin under normal physiological conditions in Pakistani population. Cross sectional study. This study was carried out at the Institute of Basic Medical Sciences, Department of Physiology, Dow University of Health Sciences, Karachi from September 2010 to September 2011. 200 apparently healthy, non-smoker and adult males of age group 30 - 50 years were selected by convenient sampling. Early morning samples of serum total testosterone and hemoglobin were obtained by venipuncture after detailed medical history and thorough physical examination. All the tests were done on the same day and results were calculated. The mean [ +/- SD] total testosterone was 15.92 [ +/- 6.32] nmol/L. The frequency of low serum total testosterone was 13.5%. The frequency of anemia was 4.0%. Hemoglobin and MCHC directly correlated with total testosterone [p < 0.05] while PCV, RBC count and MCH did not show significant correlation [p > 0.05]. Low testosterone is prevalent in Pakistani apparently healthy males in the age group 30-50 years. Significant direct relationship of testosterone with hemoglobin showed that physiological variations in testosterone can modulate hemoglobin status in middle age apparently healthy sedentary Pakistani men

Outcome of operative and non operative treatment of glenoid fossa fractures in a tertiary care hospital in Peshawar

This study was aimed at reviewing operative and nonoperative treatment of Glenoid fossa fractures in our hospital and view to identifying measures necessary to improve outcome. Retrospective study. This study was conducted at Orthopedic Department of Lady Reading Hospital, Peshawar from March 2012 to July 2014. 21 patients of glenoid fossa fractures were included in this series with 14 males and 7 females. Patients with displacement of >5 mm who were fit to undergo surgery within 3 weeks of injury were operated using a posterior Judet's approach. Overall 8 patients with displaced fractures were operated [Group A] while 9 patients with displaced fractures [Group B] and 4 patients with undisplaced fractures [Group C] were managed nonoperatively. The incidence of associated injuries was 57.14%. The mean length of hospital stay was 15.3, 32.5, and 3.9 days in groups A, B, and C, respectively. In group A, average constant score was 86.98. The least constant score was observed for group B [57.97] while group C had an average constant score of 85.9. Brachial plexus injury and fracture-dislocations had poorer outcome. Operative treatment for displaced glenoid fractures is a viable option at centers equipped to handle critically ill patients and subset of patients with fracture-dislocation as opposed to fracture alone should always be treated operatively due to persistent loss of function

Risk factors for renal dysfunction after total hip joint replacement in one territory care hospital in Peshawar

Objective: The objective of our study was to identify the possible risk factors for renal dysfunction after total hip joint replacement surgery

Study Design:Observational cohort study

Place and Duration of Study: This study was conducted in Orthopedic Department of Lady Reading Hospital, Peshawar from March 2013 to February 2014

Materials and Methods: A study was conducted among 212 consecutive primary hip joint replacements performed. According to the RIFLE criteria, increased postoperative serum creatinine was considered indicative ofpostoperative renalinjury

Results: Eighty-one patients [14.1 %] had significant moderate or severe postoperative renal dysfunction in which4 patients [1.9 %] acquired severe and permanent renalimpairment

Conclusion: We identified advanced age, hypertension, general anesthesia, high ASA scores, low intra-operative systolic BP, and prophylactic dicloxacillin as significant risk factors. Smoking, diabetes mellitus, high BMI, gender, and duration of surgery were not identified as significant risk factors