ABSTRACT
Inhaled frusemide has been shown to inhibit bronchoconstrictor responses to several indirect challenges by unknown mechanisms. In the present work, its effects on bronchoconstriction induced by inhaled metabisulphite [MBS] were studied in twelve asthmatic subjects. Frusemide significantly attenuated the response to MBS, mean value of PC20 MBS after frusemide inhalation was 25.3 mg/ml compared to mean value of 13.4 mg/ml before frusemide [t=0.624, P< 0.001]. At the same time no unwanted reactions for frusemide were observed and no duiretic effect was noticed. In conclusion, inhaled frusemide, and probably other loop diuretics, may have a practical role in the prophylaxis against asthmatic attacks
Subject(s)
Humans , Male , Furosemide , Bronchoconstrictor AgentsABSTRACT
Calculation of anion gap [AG] is an important clinical criterion in establishing the nature of metabolic acidosis [MA]. This study showed that MA as shown by high AG is not uncommon in patients hospitalized with acute exacerbation of asthma. High anion gap was found in 11 out of 20 patients with severe bronchial asthma, whose PaO2 <50 mmHg. Their AG on admission ranged between 20.6 and 39 mEq/L with a mean of 29.50 mEq/L. Fifteen out of 20 patients had absolute and relative hypercapnea, nine of them had high AG. Five patients had hypocapnea, two of them had high AG. Patients with MA ran more aggressive downhill course than those without, six of them needed artificial ventilation. It was concluded that the calculation of AG to recognize MA was not only a kind of diagnosis and evaluating the acid base status, but also it gave a greater insight of the prospect of therapy and follow up of the patients in the quagmire of critical care medicine
Subject(s)
Respiratory Insufficiency/diagnosis , Acute DiseaseABSTRACT
A technique is described to assess regional pulmonary blood flow and ventilation during normal breathing at rest, using Xenon[133] and 8 scintillation detectors. Twenty normal Egyptians were subjected to the study in erect posture. Their data show a normal pattern of increasing ventilation per unit lung volume from upper to lower zones. The right lung depicts almost better perfusion and less ventilation than the left, essentially in the lower zones. Regional V/Q ratio decreases progressively in both lungs from upper to lower zones. Correlative study was also included with arterial blood gases, spirometry and flow rates to rule out a disease error
Subject(s)
Lung Volume Measurements , Mouth Breathing , Xenon RadioisotopesABSTRACT
15 normal adult subjects were submitted to regional lung study by the radioactive gas Xe[133] after tolerable exercise of 50 Watts for 7 minutes. All persons showed more or less evening of the distribution of the perfusion with loss of the normal gradient from upper to lower zones. Ventilation was also remodelled to a better ventilation in the left lung than the right lung. The ventilation/perfusion ratio at regional levels was consequently reshaped
Subject(s)
Physical Exertion , Xenon RadioisotopesABSTRACT
15 patients with the syndrome of idiopathic interstitial lung disease have been evaluated by the rate of change in arterial oxygen tension and oxygen consumption after a modest exercise [50 Watts for 3 minutes]. There was a positive correlation between the ratio delta PO[2] [A-a]/VO[2]/m and the clinical severity of dyspnea, while the ratio delta P[a]O[2]/VO[2]/m was not significantly correlated to the same clinical parameter
Subject(s)
Pulmonary FibrosisABSTRACT
15 patients with the syndrome of chronic interstitial lung disease of unknown etiology have been evaluated hemodynamically by central right cardiac catheterization. The data of ten of them were concurrently correlated with regional lung function in comparison to the clinical severity of the disease in terms of dyspnea