Present situation of the house dust mites and its relation to currently recorded allergy in Kuwait state [the Gulf area]

The objective of this work is to investigate the present situation of the prevalent house dust mites, in general, and allergenic mites, in special, under indoor Kuwait environmental conditions, their identification, distribution, location preference, site selection and seasonal variation in houses of asthmatic patients. It also aims to investigate the relationship between the identified allergenic mites and the currently recorded allergy which has become since the mid 1950s a major cause of morbidity in Kuwait. By this, it is hoped to imply a guideline for future preventive, serological and hyposensitization measures, based on local mite fauna in Kuwait. In other words, this work would help in preparing the appropriate mite antigen as testing solution, investigating the proper testing technique and lastly providing the proper vaccines derived from the local mite fauna of Kuwait by which the patients are actually sensitized

House dust mite sensitive asthma: preliminary study on its incidence and seasonal prevalence under the Egyptian environmental conditions

The authors tried to trace incidence and seasonal prevalence of allergic bronchial asthma in relation to common aeroallergens in Egypt. The subjects consisted of patients coming to allergy clinic from urban and rural areas around Cairo. Among unselected asthmatics, the house dust mite allergy occurred more common followed by house dust. Among selected patients who were clinically sensitive to house dust, there was a higher incidence of positive skin reactions with extracts of house dust mite D. pteronyssinus, a finding which might suggest a strong correlation between mite allergens and house dust allergy under our Egyptian indoor environmental conditions.The IFA tests revealed that sera of patients sensitive to house dust mite D. pteronyssinus gave positive reactions to D. pteronyssinus and T. putrescentiace with varying degrees. This positive reaction to both antigens of Dermatophagoides and Tyrophagus might be either due to the presence of common antigens related to allergens sharing in the two mites or due to sensitization of patients by antigens from both mites patients who had positive prick tests to house dust mite D. pteronyssinus had worsening of symptoms in mid autumn and to a lesser extent during summer. It was also obvious that there was delayed rise in onset of severe symptoms which occurred, at least about two months later from peaks of live mite abundance. This was seemingly due to the disintegrated dead mites and the accumulated faecal pellets which might maximize environment pollution with mite allergens. The authors discussed their finding with those of others and introduced new suggestions

House dust mites in Kuwait: preliminary pilot survey to shed some light on diagnosis and treatment of mite allergy

The work includes the findings of a pilot survey on house dust mites in five districts of the Kuwaiti environment. This preliminary work suggests that storage mites are the predominent endophilic species, and Tyrophagus putrescentiae lies first in the order of infestation of patients houses. One D. pteronyssinus is only recorded and D. farinae is still absent. The authors discussed their findings with those of other workers at the international level and reached to a conclusion that the observations arrived at in this work are not conclusive and a detailed surveillance study on house dust mite fauna has to be undertaken before resort to any hyposensitization treatment for mite allergy in Kuwait. They shortly reviewed the role of house dust mites as causatives or transmitters of Kawasaki disease [MLNS] and suggested to mobilize researches on this disease to shed light on its position among children of the Arab world

Mass culturing of tyrophagus putrescentiae the allergenically important mite for preparation of testing antigen and desensitizing vaccine

The paper describes a convenient method for mass breeding of Tyrophagus putrescentiae the second allergenically important mite in Nile Delta and Cairo. The authors discussed the great advantage of this method to workers who intend to prepare the proper antigen and vaccine from the local storage mite fauna and which may be suitable for desensitization of our patients sensitized by house dust mites and suffering from bronchial asthma, perennial rhinitis and allergic dermatitis

Duration of the different development stages of house dust mites D farinae and D pteronyssinus under controlled condition, to pave the way in front of the workers in the field of house dust mite asthmatic

The present authors have clarified the importance of investigating the duration of the developmental stages of house dust mites for the purpose of immunoflourescence antibody test of house dust mite asthmatic bronchitis, perennial rhinitis and allergic dermatitis. This work is an addition to the previous studies and in which duration of the protonymphal, deutonymphal, and tritonymphal instars are investigated separately, the studies revealed that at 25°C and 75% R.H. for farinae and 80% R.H. for pteronyssinus shortest duration of different instars with minimal mortalities was obtained. Average durations of protonymphal, deutonymphal and tritonymphal instars of D. farinae at these most favourable temperature and relative humidity conditions were 4.2 +/- 0.8, 2.8 +/- 0.8 and 4.7 +/- 0.9 days respectively the corresponding figures of pteronyssinus were 4.3 +/- 1.2, 4.3 +/- 2.1 and 4.4 +/- 0.7, days respectively, the authors have discussed their findings with those of others in relation to the applied side of the work

Studies on dermanyssid and lealapted mites as a foundation for assessment their role in causation and transmission of diseases under our geographical zone 2 Their seasonal variation and population densities in a north

The present study reveals that Lealaps sp. 1 has two peaks of seasonal abundance, the first occurs during late spring [June] and the second during summer [August], however the former peak is much higher, being about three times greater than the summer peak. Concerning Hirstionyssinus sp., the number of mites fluctuates in the different seasons till April where there is a build up in the number reaching a single peak during late spring [June], but this peak is much lower [about 1/5] than that of Lealaps. As to Dermanyssus sp., after July there is fluctuation in the number of mites, and from April there is an abrupt increase reaching a single peak [slightly higher than that of Hirstionyssinus] during May [middle spring] after which there is a gradual decline in number of mites. The authors also found that Lealaps is the greatest in density followed by Dermanyssus and then by Hirstionyssinus. The difference between the mite density of Hirstionyssinus and Dermanyssus is relatively very small unlike that between Lealaps and the other species. Optimum temperature and relative humidity were recorded and significance of the work was pointed out; the results were also discussed

Longevity of adult mites in the laboratory as detrimental factor in indicating the peaks of environment pollution with house dust mite allergens

Studies on the longevity of live mites D. Farinae and D. pteronyssinus have led to deduce an ecological pattern for environment pollution of bed rooms with the mite allergens. Environment pollution reaches its peaks twice annually, the first occurs in mid-summer [late July] and the second in early winter [late November]. Since the two species of mites could persist climates temporarily unsuitable for breeding till the favourable environmental conditions flourish, it is expected that mites are found in different seasons but with varying densities. So, it is predicted that sensitization of patients may occur all the year round [Perennal] but the degree of sensitization varies according to rate of breeding and mortality of mites which greatly influence the strength of allergens

Duration of the development stages of house dust mites dermatophagoides farinae and d pteronyssinus under controlled temperatures and relative humidities 1 Pre-Imaginal Period

The authors have investigated the pre-imaginal period of Dermatophagoides farinae and pternyssinus under a wide range of temperatures and relative humidities. They reached to a conclusion that 25°C. is the most favourable temperature for the two species. Under this temperature, 75% R.H. and 80% R.H. yielded shortest duration periods and lowest mortalities for both farinae and pteronyssinus respectively. The authors have discussed their findings and clarified their practical importance in the field of house dust mite bronchial asthma and applied ecology of the mite under the Egyptian climatic conditions

Inquiries and suggestions on S mansoni abnormalities, recorded in vaccinated mice, and which may pay the attention to new immunogenetic insights

During the course of the present work, by using infected hepatopancreas antigen, giantism among few worms was recorded during the peak of maximum immunity. The authors discussed their finding and other abnormalities obtained by using an antigen not of the worm origin. They suggested that by using an antigen not of the parasite origin, the worms seem to be exposed to strong host defensive mechanism pressures that certain resistance genes may be found against these pressures and led to these variabilities in structure and behaviour of some of the worms. They inquired whether these variabilities can be considered as mutants under direct genetic control of mutant genes, and represent a first indication of such antagonistic forces in a trial to circumvent the defensive forces of the host. The authors also suggest some points which may pay the attention to new immunogenetic insights into an evolutionary problem of long standing