[Etiology of mid face fractures in patients referred to Imam Reza teaching hospital in 2013]

Background and objectives: Trauma is known as one of the most cause of mortality. Face is directly exposed to the various injuries of its soft tissue and bones structures. The aim of this study was the evaluation of etiology of mid faces fractures in patients

Material and Methods: This research designed as a cross-sectional study and 64 patients which were referred to the department of Oral and Maxillofacial Surgery of Imam Reza teaching hospital were selected. All data were recorded in the special forms as retrospective manner. Data included age, gender, treatment type and symptoms of the trauma. Results were analyzed by descriptive statistics [mean and standard deviation and percent - frequency]

Results: Among 64 patients, 51.6% of fractures were related to the accidents. 87.5% of the patients were male in which most fractures occurred at mean age of 32.2 +/- 13.8 with frequency of 35.9%. Most of the fractures happened in spring and summer

Conclusion: The most common injured site was zygoma bone with the frequency of 87/5%

effect of interleukin 36Gene therapy in the regression of tumor

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. Recently, interluekin36 [IL36] has been used as immunotherapeutic agents in cancer gene therapy. Present study investigated that the IL36 gene therapy effects on the regression of tumor masses in mouse model. Aim of this study is determination of the gene therapy effects by IL36 in the regression of tumor masses in mouse model. To study the therapeutic efficacy of this cytokine, WEHI-164 tumor cells were transected with mIL36 plasmids. ELISA test was used to check cytokine production by transected cells. To establish fibro sarcoma mouse model, Tumoral transfected cells were injected subcutaneously to inoculate tumor in BALB/C mice. Tumor volumes were measured by caliper. Mice were sacrificed and tumors were extracted. The expression of IL36 and IFN-gamma was studied with Real-time PCR and immunoblotting. The expression of Ki-67 [a tumor proliferation marker] in tumor masses was studied by immunohistochemistry staining. In this study we had 2 groups which are treated with IL-36 and Untreated with IL-36 as a blank. The group treated with IL36 indicated decrease of tumor mass volume [p<0.001]. The results of western blotting and real-time PCR showed the IL36 expression increased in the group treated with IL36 [with relative expression of 1.9]. Immunohistochemistry staining indicated that the Ki-67expression has been reduced in the group interfered with IL36. IL36 gene therapy has therapeutic effects on the regression of tumor masses in fibro sarcoma mouse model

[Giant cell fibroma of the tongue: a case report]

Giant cell fibroma of the tongue is a rare benign fibrous tumor of connective tissues in the oral cavity, very few of which have been reported. This benign neoplasm has a predilection for the gingiva and usually occurs in women under 30. Since this tumor is clinically, and especially histopathologically, placed in the differential diagnosis list of benign and malignant mesenchymal tumors, its proper diagnosis is of great significance because widespread and unnecessary surgeries are avoided as a result. The aim of the present report is to present a case of the tumor in the tongue of a 65-year-old man. The fibroma is a benign fibrous tumor of connective tissues which is microscopically classified in differential diagnosis with other soft tissue tumors since its proper diagnosis prevents from extensive and unnecessary surgeries on the patient