[Antisense technology]

In 1978, Zamecnik and Stephenson explored that how nucleotides as antisense agents can inhibit viral replication process in vitro. Since that time antisense technology has been developed as a strong facility for therapeutic usages. Antisense molecules are complementary nucleic acids which specifically bind to the target mRNA and inhibits its translation. Theoretically, antisense molecules could be used to control over expressions of genes and related disorders like viral diseases, inflammations, cancers, etc. Despite of their simple structures, there are serious challenges for using of these materials which should be resolved in near future