ABSTRACT
ABSTRACT Objective To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. The moderator role of 25(OH)D in the association of MetS, its diagnostic components and IR with hsCRP were also explored. Materials and methods A cross-sectional study (2014/2015) with a population-based cohort in Southern Brazil (n = 605). Metabolic syndrome (MetS) diagnosis was defined based on the Joint Interim Statement, while the Homeostasis Model Assessment of insulin resistance (IR) (HOMA-IR) was used for determining IR. Serum concentrations of 25-hydroxy vitamin D [25(OH)D] (ng/mL) and high sensitivity C-reactive protein (hsCRP) (mg/L) were evaluated following standard protocols. 25(OH)D was categorized as sufficiency (>30 ng/mL), insufficiency (20-30 ng/mL) or deficiency (<20 ng/mL) to test its moderator role. Multiple linear regression was used to test the associations. The results were adjusted for possible confounders. Results and discussion Hypertriglyceridemia and IR were associated with lower 25(OH)D concentrations. However, except for systolic blood pressure, other MetS components and IR were associated with higher hsCRP. The association between elevated waist circumference (WC) and hsCRP was moderated by the 25(OH)D concentrations. The hsCRP median concentrations were more than two times higher among those with elevated WC and 25(OH)D insufficiency or deficiency. In this study, inadequate concentrations of 25(OH)D increased the adverse relationship between elevated WC and inflammation. 25(OH)D concentrations could be incorporated into the clinical protocols for monitoring individuals with abdominal obesity to identify those at a higher risk of complications.
Subject(s)
Vitamin D Deficiency/complications , Insulin Resistance , Metabolic Syndrome , Vitamin D , Brazil , C-Reactive Protein , Cross-Sectional StudiesABSTRACT
RESUMO: Objetivo: Analisar as associações entre mudanças do nível de atividade física de lazer em adultos com a prevalência de síndrome metabólica. Métodos: Estudo de base populacional realizado com 818 adultos de 20 anos ou mais em Florianópolis, Santa Catarina, entre 2009 e 2014. Testou-se a associação da manutenção e/ou mudança do nível de atividade física com a prevalência de síndrome metabólica, ajustada por variáveis sociodemográficas (sexo, idade, escolaridade, renda, estado civil e cor da pele) e tabagismo. Empregou-se regressão logística, estimando-se as razões de chance (OR) e os respectivos intervalos de confiança (IC95%). Resultados: A prevalência geral de síndrome metabólica foi de 30,9% (IC95% 27,2 - 34,7). Independentemente das variáveis de ajuste, os adultos que deixaram de ser ativos e/ou se mantiveram fisicamente inativos no lazer no período apresentaram, respectivamente, 108 e 124% maiores chances para a síndrome metabólica (OR = 2,08; IC95% 1,30 - 3,33) e (OR = 2,24; IC95% 1,38 - 3,65). As mulheres e os indivíduos com idade inferior a 45 anos apresentaram menores chances para a síndrome metabólica. Conclusões: Nesta amostra, manter-se inativo ou passar a sê-lo associou-se, significativamente, com maiores chances para a síndrome metabólica.
ABSTRACT: Objective: To analyze the associations between changes in the level of leisure-time physical activity in adults and the prevalence of metabolic syndrome. Methods: This is a population-based study conducted with 818 adults aged 20 years or older from Florianópolis, Santa Catarina, Southern Brazil, between 2009 and 2014. We tested the association of maintenance and/or changes in the level of physical activity with the prevalence of metabolic syndrome, adjusted for sociodemographic variables (gender, age, schooling, income, marital status, and ethnicity) and smoking habits. We used logistic regression and estimated the odds ratios (OR) and their respective confidence intervals (95%CI). Results: The overall prevalence of metabolic syndrome was 30.9% (95%CI 27.2-34.7). Regardless of adjustment variables, adults who ceased to be active and/or remained physically inactive during leisure time in the study period presented, respectively, 108 and 124% higher odds of developing metabolic syndrome (OR=2.08; 95%CI 1.30-3.33 and OR=2.24; 95%CI 1.38-3.65). Women and individuals younger than 45 years showed lower odds of having metabolic syndrome. Conclusions: This sample presented a significant association between remaining or becoming inactive and a greater chance of developing metabolic syndrome.
Subject(s)
Humans , Male , Female , Adult , Exercise , Metabolic Syndrome/epidemiology , Leisure Activities , Brazil/epidemiology , Prevalence , Risk Factors , Sedentary BehaviorABSTRACT
Resumo Introdução Exames complementares podem contribuir para a compreensão da etiologia de agravos à saúde de idosos. Objetivo Descrever os aspectos operacionais e protocolos referentes à coleta, análise e armazenamento de material biológico, exames de imagem e capacidade físico-funcional. Método Estudo longitudinal, de base populacional, com 604 idosos (≥ 60 anos) do estudo EpiFloripa Idoso, em 2014. Foram coletados dados de material biológico, composição corporal, densitometria óssea, ultrassonografia da espessura íntima média das artérias carótidas, força de preensão manual e a atividade física. Resultados A taxa de resposta foi de 50,4%. Houve perda de seguimento em relação à faixa etária, estado cognitivo e atividades de vida diária. Os indivíduos que realizaram os exames eram mais novos, trabalhavam no momento da entrevista, ingeriam álcool, eram fisicamente ativos. Além de apresentarem menor grau de dependência, ausência de déficit cognitivo, ausência de sintomas depressivos e ausência de dificuldade na mobilidade. Conclusão Espera-se que a descrição das rotinas aplicadas possa auxiliar no desenvolvimento de novas pesquisas semelhantes em grupos de idosos. Assim, poderá ser acompanhado o processo de envelhecimento da população, seus fatores de risco e proteção.
Abstract Background Complementary exams may contribute to the understanding of the etiology of health problems in older adults. Objective To describe the operational aspects and protocols used to collect, analyze and storage biological materials, image exams and physical-functional capacity tests. Method This is a longitudinal and population-based study with 604 older adults (≥ 60 years) from EpiFloripa Ageing Study, in 2014. Data of biological material, body composition, bone densitometry, ultrasonography of the carotid artery intima average thickness, hand grip strength and physical activity were collected. Results The response rate was 50.4%. There was loss of follow-up in relation to age, cognitive status, and activities of daily living. The individuals who performed the tests were younger, worked by the time of the interview, ingested alcohol and were physically active. Also, they were less dependent, absence of cognitive impairment, absence of depressive symptoms and absence of difficulty in mobility. Conclusion It is expected that the description of the applied routines may help in the development of new similar research in the older adult population. Thus, the aging process of the population, its risk and protection factors can be followed.