ABSTRACT
The study on natural substances especially, dietary components such as liquid oils affecting cholesterol can be important for therapeutic propose. Sesame seeds with various biomedical actions can be control the hypercholesterolemia. On the other hand, olive oil has a wide range of therapeutic effect on lipid profile in human. The aim of this study is to evaluate and compare lipid profile changes after olive and sesame oils consumption in hypercholesterolemia. This study was a clinical randomized trial that was performed via parallel design on 48 patients. The patients were randomly allocated in to two groups: A: olive oil and B: sesame oil. After 1 month prescription of Step I National Cholesterol Education Program diet, patients consumed 4 table spoons aprox. 60 g] of refined olive or sesame oil daily as an exchange of other oils, for 1 month. Lipid profiles The P < 0.05 was considered as significant difference. Out of 48 patients, 24 [50%] were men. The mean age was 41.7 +/- 8.3 years. The mean of total cholesterol, triglyceride [TG], low density lipoprotein [LDL], cholesterol, and high density lipoprotein [HDL] cholesterol, before oil consumption was 224.5 +/- 22, 256 +/- 132, 132.6 +/- 9, and 44.5 +/- 11 mg/dl. After olive oil consumption cholesterol, TG, LDL-C, weight, waist and BMI were decreased and HDL-C was increased. After sesame oil consumption cholesterol, TG, LDL-C were significantly decreased. Weight, waist were decreased and HDL-C was increased [P > 0.05]. Sesame oil had equivalent effect on lipid profile in comparison olive oil and lipid profile improvement was better in sesame oil in LDL-C and TG
ABSTRACT
Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic patients. Purpose of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. In this study 31 type 2 diabetic patients with Fasting blood Sugar [FBS]:140-200 mg/dl, Triglyceride [TG]: 200-400 mg/dl, Cholesterol [TC]: 200-300 mg/dl and mild hypertension were selected. Subjects received vitamin E 800 IU/day for 3 months. At the baseline and end of the study FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. In this study 31 type 2 diabetic patients [19 female, 12 male] with mean age 53.03 +/- 8.87 years were studied. Vitamin E supplementation for 3 months had no positive effect on type 2 diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also total Cholesterol, systolic and diastolic blood pressure changes were not remarkable. Results of this study showed that 800 IU vitamin E administration for 3 months could not improve blood glucose, lipids, HbA1c, fasting insulin, systolic and diastolic BP in type 2 diabetic patients