ABSTRACT
Statement of the Problem: Macrophages are the target of attention in numerous diseases. Many studies reported them as the regulators of the growth, dissemination, and clinical behavior of various lesions. There are relatively scarce data regarding the role of macrophages in oral lesions, particularly odontogenic lesions
Purpose: This study investigated the macrophage density in odontogenic lesions of diverse biologic performance
Materials and Method: In this comparative analytical study, 60 cases of odontogenic lesions including ameloblastoma, keratocystic odontogenic tumor, dentigerous cyst, and radicular cyst were immunohistochemically stained with anti-CD68 antibody. One-way ANOVA and Tukey's HSD test were used for statistical analysis
Results: The results showed that the macrophage density in keratocystic odontogenic tumor [35.72+/-7.74] and ameloblastoma [46.12+/-9.84] was not significantly different from that in dentigerous cyst [43.87+/-8.13]. Interestingly, the macrophage density in keratocystic odontogenic tumor was lower than that in dentigerous cyst. No significant difference was observed in macrophage density between the ameloblastoma and much less aggressive lesions like dentigerous cyst [p= 0.59]. Macrophage density in radicular cyst [81.53+/-11.04] was significantly higher than other odontogenic lesions [p< 0.001]
Conclusion: The lack of significant differences in macrophage density between the known aggressive odontogenic tumors and much less aggressive lesions implied that macrophages might not contribute to the biological behavior of the odontogenic lesions. Therefore, it could support the notion that targeted therapy would not have prominent clinical potential to decrease the extent of mutilating surgeries in odontogenic lesions
ABSTRACT
Statement of the Problem: Lichen planus disease is a chronic inflammatory lesion without a known etiology. Recent studies have indicated the role of vitamin D on immune system and proposed its anti-inflammatory effects
Purpose: This study aimed to compare vitamin D serum levels in patients with oral lichen planus and healthy subjects
Materials and Method: In this case.control study, 18 patients suffering from oral lichen planus referred to the Department of Oral Medicine, Tabriz Faculty of Den-tistry were chosen as the case group and 18 healthy people were chosen as the con-trol group. A 5-mL blood sample was taken from all subjects and the subjects' vitamin D serum levels were assessed with a vitamin D total [25-hydroxy vitamin D] kit by employing the electrochemiluminescence technique. The results were analyzed and compared by using SPSS17 statistic software. p< 0.05 was considered statistically significant
Results: The mean vitamin D level in serum of patients with oral lichen planus was 30.7+/- 20.38ng/ml and in healthy subjects was 36.45 +/- 15.33ng/ml, the difference was not statistically significant [p= 0.346]
Conclusion: The difference between the level of vitamin D in the serum of patients suffering from oral lichen planus and healthy individuals was not significant
ABSTRACT
Objective: Shear bond strength is an important property inherent to the durability of tooth-colored restorative materials namely composite resins. It has been years that halogen light sources have been used for polymerization of composite resins. In recent years Light Emitting Diodes [LED] have been introduced for this purpose. With respect to their longer bulb life, needless of a filter and no heat production, the demand for their use has increased. This study aimed to compare three different LED curing-lights with conventional Quartz Tungsten Halogen [QTH] lights to assess their effects on shear bond strength of composite to dentin
Methods: In this laboratory study, 60sound caries-free premolar teeth, after disinfection with sodium hypochlorite and cleaning with a scaler, were divided into four groups of 15. After the specimens had their dentin surface exposed with a metal disc, the composite restoration was done
The restorations in each group were done using Single Bond bonding agent and cured with the QTH light curing units and three different LED curing devices. Next, the strength of each bond was measured with an Instron Machine. The results were analyzed with one-way ANOVA and Tukey's test
Results: Analysis of the data with one-way ANOVA revealed statistically significant differences between the groups [p<0.05]
The greatest bond strength related to the LED light in ramp mode with 114.68 Newtons [N] or 22.94megapascals [MPa].The lowest related to the pulsed-LED with a mean of 70.35N [14.70 MPa]. In pair wise comparison of the 4 groups with Tukey's test, all groups with the exception of QTH with a mean of 99 N [19.80 MPa] and the conventional LED with a mean of 86.78N [17.35 MPa], had a significant difference [p<0.05]
Conclusion: Our study showed that the use of LED light in ramp mode had better results compared to the QTH light source [control group] [p=0.38]. Conventional LED light was comparable to the QTH light as well [p=0.169]?