ABSTRACT
Background: Coronary morbidity. It is characterized by the activation and aggregation of the platelet, thrombus formation and myocardial infarction. During recent years, many epidemiological studies on risk factors of CAD have been performed which are fibrinogen, lipoprotein [a], and hemocystein as new CAD risk factors. The aim of the present study was to evaluate of plasminogen., fibrinogen and plasmin [PAP] levels in plasma including in patients of non-diabetic and smoker as the hemostatic parameters and their association with CAD to prevent progression of disease
Methods: In this study selected 120 subjects including 60 patients who underwent coronary angiogfaphy ancl 60 controls from blood donors of blood bank who had no history of CAD and liver disease and cancer. To determined Plasma levels plasminogen and PAP used ELISA Procedure [Bioassay technology laboratory kit] and plasma level of fibrinogen used Clauss method by kit of Mahsa yaran
Results: Plasma levels of plasminogen and plasmin anti plasmin [PAP] in patients with CAD were found to be significantly lower than control group [p<0.05 both of them]. Moreover Plasma level of fibrinogen in patients were significantly higher than control group [p< 0.05]
Conclusion: Elevated plasma levels of fibrinogen participate in atherogenesis leading to CAD. These finding suggested plasma level of fibrinogen can be useful as a diagnostic and monitoring marker in patients with CAD. Plasmin and plasminogen deficiency may participate in progressing CAD and thrombus formation and impaired jibrinolysis
Subject(s)
Humans , Fibrinogens, Abnormal , Plasminogen , Smokers , Morbidity , Coronary Thrombosis , AtherosclerosisABSTRACT
Background and Objectives: Coronary Artery Disease [CAD] Occurs as a result of atherosclerosis. There are several factors which are closely associated with CAD. Cell adhesion molecules such as Vitronectin [VN], could play an important role. The aim of the present study was to evaluate the VN and hs-CRP levels in a group of NonSmokers with CAD and correlation with extent and Severity of CAD
Material and Methods: In this study 200 person included: [160 patient and 40 controls]. Patients were divided based on angiographic findings in to 4 groups including: 40 individuals with no vessel disease, 40 individuals with single vessel disease, 40 individuals with double vessel disease and 40 individuals with triple vessel disease. The control group had no history of heart disease. Exclusion criteria were factors such as liver, kidney and lung diseases and malignancies. Serum levels of VN were determined by [ELISA] method [Glory Science] and serum concentration of hs-CRP was measured by Immunoturbidometric method
Results: The mean age of patient and controls were [58 +/- 7 years and 56 +/- 8]. There was no significant difference between the two groups in their age and sex. Serum VN and hs-CRP levels in patient groups were significantly higher than control groups [p<0.05 for all]. Moreover, serum levels of VN in patients with triple-vessel and one-vessel disease were significantly higher than control group [p<0.05 in all cases]. Serum levels of hs-CRP in patient groups were significantly higher than controls [p<0.05]
Conclusion: Serum levels of Vitronectin and hs-CRP were significantly higher in Non-Smoker CAD patients as in comparison with controls. Their association with the extent and severity of the lesion was present also
ABSTRACT
Background and Objectives: Nitric Oxide [NO] is the relaxing factor of endothelium and may contribute to atherosclerosis. Decrement of Antioxidants is another risk factor for Coronary Artery Disease [CAD] in Non-diabetic individual. This study was designed to investigate the NO concentration and Antioxidants levels in a group of patients with CAD in North West of Iran
Materials and Methods: One hundred fourty person studied, including 70 patients with angiographically diagnosed CAD and 70 age and sex matched normal controls were studied. Exclusion criteria were; diabetes, malignancies and liver disease. The levels of Nitric oxide in the serum samples of each individual were measured by Griess Method. The activities of SOD and GPX and Total Antioxidant Capacity were determined using Randox Kits on an automated chemical analyzer [Abbott, model Alcyon 300, USA]
Results: We found diminished levels of NO in CAD groups compared to controls [P<0.05]. Erythrocyte SOD, GPX activities and TAC level were reduced significantly in CAD patients [P<0.05 in all cases]
Conclusions: The low levels of NO might be another risk factor for progression of coronary artery disease in the non-diabetic patients. Decrease of Antioxidants also may suggest their involvement in atherosclerosis