ABSTRACT
Oxidative stress induces different diseases, such as diabetes, cancer, arteriosclerosis and Alzheimer. In this study, the antioxidant effect of hydroalcoholic extract of Salvia officinalis was investigated. In this experimental study, isoniazid, as an anti tuberculosis agent, has been used to induce free radicals. Male rats were used and divided in 9 groups; in each group, 7 rats were included. Isoniazid with dose of 50 mg/kg was orally administered to rats continuously once per day for 28 days using a feeding atraumatic needle. The treated groups received hydroalcoholic extract of Salvia officinalis with the doses of 100, 250 and 400 mg/kg intraperitonally, and the effects of the extract and isoniazid on liver enzymes such as aspartate aminotransferase [AST], alanin aminotransferase [ALT], alkaline phosphatase [ALP] and gama glutamyl transferase [GGT] were studied. Serum levels of AST, ALT, ALP and GGT and also hepatic histopathologic observations indicated that the effective doses of Salvia officinalis extract were 100 and 250 mg/kg. This study showed that Salvia officinalis hydroalcoholic extract is potentially effective in the reduction of damages caused by oxidative stress