Some platelet disorders in chronic idiopathic thrombocytopenic purpura and chronic myloid leukaemia

Thirty in-patients in the Department of General Medicine of Assiut University Hospital with thrombocytopenia were studied before treatment, twenty patients with chronic idiopathic thrombocytopenic purpura and ten patients with chronic leukemia [nine had chronic myeloid leukemia and one with lymphocytic leukemia]. The study also included ten normal individuals served as controls. Careful history and clinical examination were carried out for every patient and normal individual complete blood picture, bleeding time, clot retraction, prothrombin time, kaolin cephalin clotting time, platelet volume study including mean platelet volume and platelet volume distribution and platelet factor-3 availability were done. Statistical analysis of the results showed that patients with chronic idiopathic thrombocytopenic purpura had significantly prolonged bleeding time and reduced clot retraction, but there was no significant difference in prothrombin and kaolin cephalin clotting times between patients and normal individuals. They also had significantly increased mean platelet volume which varied inversely in linear pattern with platelet count. This linear inverse relation in chronic idiopathic thrombocytopenic purpura was the same in the control group. There was significantly increased mean percentage of microplatelets [3-6 FL] and large platelets [13 FL]. Also, 60% of patients with chronic idiopathic thrombocytopenic purpura had diminished platelet factor-3 availability. This analysis showed that patients with chronic leukemia had significant prolongation in bleeding time and reduction in clot retraction. They also had significant prolongation in prothrombin time and platelet volume study. Patients with chronic myeloid leukemia revealed significant increase in the mean platelet volume and in the mean percentage of large platelets [13 FL]. There was also a linear inverse relation between the mean platelet volume and platelet count. Platelet factor-3 availability was diminished in 70% of patients

Socio psychological factors in obesity

This study included 184 obese patients, 80 were males and 104 were females. Their ages ranged from 11-60 years with mean +/- SD of 28.31 +/- 15.87 years. The patients were classified into 4 groups according to their age and sex into males and females above or below 20 years. For each patient a detailed history was taken, stressing mainly on 27 point special questionnaire and 105 questions for determination of the 16 personality factors according to Cattel et al. [1972]. We found that males and females less than 20 years [M< 20 Y and F < 20 Y] significantly preferred soft drinks, watching television for a long time, and had higher income among their families compared to other groups. while obese patients above 20 years significantly [P< 0.01] felt shame and blamed about their shape, used cars more and had higher prevalence of organic diseases compared to other groups. Sixteen patients among obese above 20 years had juvenile onset obesity, 7 [10.8%] were females and 9 [22.5%] were males. No psychological diseases, affection of mentality or success in weight reduction were found among the 4 groups of patients. F < 20 Y and M > 20 significantly [P < 0.01] preferred eating carbohydrates compared to the other groups. [F > 20 Y], significantly preferred eating fatty meals, peanuts and seeds, and had less activity compared to the other groups. F < 20 Y significantly played exercises, and had more desire for eating during excitement compared to the other groups. The family history of obesity was significantly higher [P < 0.01] among M < 20 Y [82.5%] compared to M > 20 y [60%]. Both F < 20 y and F > 20 y preferred fine manual work significantly [P < 0.01] than the other groups. M < 20 y preferred reading for a long time significantly [P < 0.01] more than M > 20 Y. As regards the 16 personality factors impulsivity scores were significantly [P < 0.01] higher among F < 20 Y compared to F > 20y, while tension scores were significantly higher [P < 0.01] in F > 20y compared to F < 20y