ABSTRACT
@#Introduction: The purpose of this research was to analyze the relationships between pharmacists knowledge, work environment, and self-efficacy to their compliance level with the COVID-19 health protocols. Methods: This cross-sectional study was designed with descriptive correlational data collection using a questionnaire. Simple random sampling was used to choose the participants who are pharmacists from the Special Region of Yogyakarta’s Province. The demographic characteristics of the respondent were presented descriptively. The demographic characteristics of the respondent were presented descriptively. A statistical test was used to assess the correlation between compliance level vs each of the three factors from the Social Cognitive Theory. Results: A total of 262 pharmacists were selected with data collection using a questionnaire. Most of them were in a medium level of compliance (65.6%), while only 19.1% in a high level, and the 15,3% in a low level. Correlation values of 0.463 and 0.409 between variables measuring the organization’s environment and self-effciacy were found to be statistically significant at the p value <0.05. Meanwhile, there was no statistically significant relationship between knowledge and compliance (p>0.05) with correlation value was 0.054. There is good compliance to the COVID-19 health protocols among community pharmacists in the Special Region of Yogyakarta. Conclusion: These findings indicate that improving factors from pharmacy organization-environmental and self-efficacy of pharmacists may improve community pharmacists level of compliance to COVID-19 health protocols in pandemic era.
ABSTRACT
ABSTRACT@#Green tea (Camellia sinensis) has high level of flavonoids which are proven to have anti-inflammatory activity. Effect of flavonoids can be enhanced by nano-chitosan capsulation as drug carrier. Chitosan is polysaccharide derived from crustacean shells that mostly used as matrix of various drugs and plant extracts. The aim of this study was to determine the effectivity of flavonoids in green tea extract in nanochitosan capsulation towards the number of fibroblasts on proliferative phase of gingival wound healing process. Green tea was extracted, encapsulated with nano-chitosan and then made into gel. Gingiva labial of 24 male white 3-month-old Wistar rats were wounded by punch biopsy (2 mm diameter), then were treated two times a day, and were divided randomly into four groups of topical gel applications: green tea extract gel encapsulated nano-chitosan, green tea extract gel, base gel as negative control, and NSAIDs gel as positive control, starting at 0 day until 7th day. At 5th and 7th day, three rats from each group were decapitated and the mandibular gingiva was taken in order to make histology slides with hematoxylin eosin staining. Under microscope, the number of fibroblasts were examined. The data were analysed using ANOVA test with 95% confidence level. The results showed that the number of fibroblasts on proliferative phase was significantly higher than control negative (p < 0.05) and has no significant differences (p > 0.05) with control positive. In conclusion, topical application of green tea extract gel encapsulated nano-chitosan was effective to accelerate rats gingival wound healing process by increasing the fibroblasts.