Toxic effect of paroxetine on electroencephalogram, thyroid function and ainino acids in rat

In the present study, the effects of acute and chronic [up to 30 days] treatment with paroxetine on electroencephalogram, amino acids, T[3], T[4], ALT, AST and Urea have been investigated. Furthermore, paroxetine concentrations in different organs of rats at the same time points have been measured. Chronic administration of paroxetine significantly increased ALT, AST activities, Urea, and T[3] levels while reduced T[4] levels. The drug also altered amino acids metabolism in liver and brain. Paroxetine showed EEG changes with pronounced stimulation and produced some dysphoria, sedation and hallucination effects similar to serotonin syndrome drugs

Effects of mobile phones radiation on the EEG and EMG of human users

This study focuses on the effect of mobile phone radiation emissions on the human electroencephalograph [EEG] and electromyogram activity [EMG]. EEG and EMG recordings from 50 [male and female] awake subjects were taken during exposure to radiation emissions from a mobile phone. Our results demonstrated that stimulation effects became apparent on EEG at first, and changes varied strongly at the end of the experiment to depression. EEG and EMG showed interesting changes.The results suggested that cellular phones may reversibly influence the human brain, as their use induced abnormal slow waves in EEG of awake persons

Toxic effects of some antispastic drugs on the EEG: some biochemical and immunological studies on rats

The toxicity of tizanidine and baclofen was studied on male rats. The oral clinical dose of tizanidine and baclofen[0.216 and o.54 mg/ 100g body weight / day, respectively]was given for one, two, three and four weeks. Chronic administration of the two drugs causes damage to the lung and a significant reduction in serum and lung levels of GSH , Vit E , Vit C and SOD activity . Four weeks treatment induced significant elevation of GPX activity and MDA levels. The two drugs, also, caused inhibitory activity on proliferation of splenocyte triggered by Con A, LPS and IL-2 production cell activities. They also produced several abnormal patterns in the EEG including increased epileptiform discharges and synchronous rhythmic activity . Diffuse slowing , with increased beta and delta activity and decreased alpha activity , with superimposed beta activity were recorded. Tizanidine had more prominent effect on the EEG than baclofen

Toxic effects of paroxetine on sexual and reproductive functions of rats

This study determined some appropriate parameters to detect male and female reproductive, endocrine, and teratological toxicity besides genotoxic effects of paroxetine. Several parameters concerning fertility were measured in male and female rats given oral doses of paroxetine [0.36mg/100g b.wt./day] for a month. In addition, estimation of the drug residues in male, female and fetus were carried out. There were alterations in serum concentration of gonadotraphins: FSH, LH, PRL and in the sex hormones: testosterone, progesterone and estradiol in male and female rats. These alterations were accompanied by sperm reduction, sperm abnormalities, irregular shaped of seminiferous tubules, hypertrophy of geominal cells and structural chromosomal aberrations in male rats. A reduction in mating and fertility indices were observed with an increase in the number of resorbed fetuses, and a decrease in body weight and crown rump length of rat embryos