ABSTRACT
Objective: to determine the frequency of dyslipidemia in normotensive, non-diabetic obese patients
Methods: it was a cross sectional study including admitted patients and patients visiting outdoor. After obtaining informed consent, demographic information such as name, age, gender was collected .This study included 200 normotensive, non-diabetic obese patients. Serum lipid profile was checked in all patients. The frequency and pattern of dyslipidemia was assessed which was described in frequency distribution tables
Results: the mean total Cholesterol, mean LDL C, HDL and Triglyceride levels were 211.59 +/- 42.39 mg/dl, 131. 39 +/-17.21 mg/dl, 36.46+/-7.93 mg/dl and 164.69 +/- 11.80 mg/dl, respectively. The dyslipidemias were found in 87 [43.5%] patients
Conclusion: the frequency of dyslipidemias is high among normotensive non diabetic obese patients. So, every patient with obesity should be screened with lipid profile
ABSTRACT
Objective: the objective of the study was to determine the diagnostic accuracy of prothrombin time for the non-invasive diagnosis of esophageal varices keeping upper gastrointestinal endoscopy as Gold Standard
Methods: the study was conducted in Medical unit 4, Services Hospital Lahore over a period of 6 months. It is a cross-sectional study
Results: in our study, 43.5%[n=87] were between 12-30 years and 56.5%[n=113] were between 31-60 years, mean+/-sd was calculated as 39.90+/-12.29 years, 43.5%[n=87] were male and 56.5%[n=113] were females, frequency of esophageal varices keeping upper gastrointestinal endoscopy as gold standard was recorded in 57%[n=114] while 43%[n=86] had no findings of the morbidity, diagnostic accuracy of prothrombin time for the non-invasive diagnosis of esophageal varices keeping upper gastrointestinal endoscopy as gold standard 53%[n=106] true positive, 2%[n=4] false positive, 4%[n=8] false negative and 41 %[n=82] as true negative. Whereas specificity, sensitivity, positive predictive value, negative predictive value and diagnostic accuracy was calculated as 92.98%, 95.35%, 96.36%, 91.11 %, and 94% respectively
Conclusion: we concluded that the predictive value of prothrombin time for presence of oesophageeal varices is a higher and it is a useful non-invasive diagnostic modality
ABSTRACT
Objective: to determine the frequency of thyroid dysfunction in patients of chronic hepatitis C treated with Interferon alpha 2b and Ribavirin
Methods: a total of 120 cases having active hepatitis C assessed by HCV RNA PCR as per operational definition for at least 3 months between 15 years to 60 years of both gender were included in the study from outdoor of Services Hospital Lahore after a written informed consent. All the demographics including name, age, gender and address were entered in a pre-defined questionnaire. Patients were treated with Interferon alpha 2b [dose] three million international units subcutaneously three times a week and Ribavirin [dose] 1200 mg oral dailyfor24 weeks. As per hospital routine Thyroid dysfunction was evaluated as per operational definitions bycollecting4ml of blood in a 5cc syringe at 0 [baseline] and 12 week. Presence or absence of thyroid dysfunction at 12 weeks was labelled as per operational definition
Results: in our study, out of 120 cases, 42.5% [n=51] were between 15-40 years while 57.5% [n=69] were between 41-60 years of age, mean +/-sd was calculated as 42.49+/-11.54 years, 59.17% [n=71] were male while 40.83% [n=49] were females, frequency of thyroid dysfunction in patients of chronic hepatitis C treated with interferon alpha 2b and ribavirin was recorded in 21.67% [n=26]
Conclusion: we concluded that the frequency of thyroid dysfunction in patients of chronic hepatitis C treated with Interferon alpha 2b and Ribavirin is not very high but reaches at a considerable level and necessary steps should be taken for the management of this morbidity while interferon therapy is given to the Hepatitis C virus cases