ABSTRACT
BACKGROUND: The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. METHODS: Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels. RESULTS: ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P0.05). CONCLUSIONS: These finding suggested that oxidative stress is associated with hepatitis B activity.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Alanine Transaminase/blood , Antioxidants/metabolism , Carrier State , Catalase/blood , DNA, Viral/analysis , Fibrosis , Hepatitis B/metabolism , Hepatitis B Surface Antigens/blood , Hepatitis B virus/genetics , Hepatitis B, Chronic/metabolism , Lipid Peroxidation , Oxidative Stress , Sulfhydryl Compounds/bloodABSTRACT
Background: We aimed to examine cases of brucellosis that presented with severe thrombocytopenia and hemorrhagic diathesis
Methods: A total of 10 brucellosis cases with severe thrombocytopenia were included in this case-series study. Patients' files were reviewed for their clinical and laboratory findings, as well as clinical outcomes and complications. Platelet counts of<20000/mm[3] were diagnosed as severe thrombocytopenia
Results: The lowest thrombocyte count was 3000/mm[3] while the highest was 19000/mm[3] [mean: 12000/mm[3]]. Patients had the following symptoms: epistaxis [7 cases], petechia with epistaxis [4 cases], bleeding gums [3 cases], ecchymosis with epistaxis [2 cases], melena and renal failure [2 cases], and hematuria [1 case]. Patients were given rifampicin and doxycycline along with supportive hematological therapy. All were treated successfully with no evidence of recurrence at follow-up visits
Conclusion: Since brucellosis is endemic in developing countries, it must be considered in the differential diagnosis of cases that present with severe thrombocytopenia and hemorrhagic diathesis
Subject(s)
Humans , Female , Male , Adolescent , Adult , Middle Aged , Thrombocytopenia , Hemorrhagic DisordersABSTRACT
Neurobrucellosis is one of the complications of brucellosis. We report a rare case of a 17-year-old girl with seronegative neurobrucellosis and depression and diplopia. Results of agglutination tests for Brucella both in serum and CSF were negative. Diagnosis was made only by positive culture of Brucella mellitensis with inoculation of the patient's cerebrospinal fluid in a BACTEC 9050 System. The patient was successfully treated using ceftriaxone, doxycycline and rifampicin therapy for six months