ABSTRACT
BACKGROUND: Bushen Huogu decoction can effectively prevent and treat osteoporosis, but the concrete mechanism of pharmacology is still not clear. 25-hydroxy vitamin D3 and 1, 25-dihydroxyvitamin D3 are important coupling factors, which can regulate bone resorption and formation.OBJECTIVE: To investigate the curative effects of Bushen Huogu decoction on the bone mineral density, bone biomechanics, and level of 25-hydroxy vitamin D3 and 1, 25-dihydroxyvitamin D3 in blood serum, liver and kidney in the ovariectomized osteoporotic rats.METHODS: Totally 108 healthy female Sprague-Dawley rats were randomly divided into model group, sham-operated group, andtreatment group. All rats had been ovariectomized to induce estrogen absence and further establish osteoporotic models, except those in sham-operated group. Treatment group of rats were intragastrically administrated with 2 mL Bushen Huogu decoction,twice a day.RESULTS AND CONCLUSION: Compared with model group, the bone mineral density in the rat femur was significantly increased in the treatment group (P 0.05). In the early period of estrogenic hormone absence, the Chinese kidney-tonifying drugs could activate bone metabolism, raise bone mineral density and reinforce quality of bone through up-regulating expression of 25-hydroxy vitamin D3 and 1,25-dihydroxyvitamin D3.
ABSTRACT
Objective To investigate the clinical effects of surgery treatment of the Tibia plateau fracture.Methods Thirty-two cases diagnosed Tibial plateau fracture were performed internal fixation and bone grafting surgery treatment.Results According to Rasmussen Evaluation,there were the gifted 22 cases(68.8%)excellent,6 cases(18.8%)good,2 cases(6.3%)ordinary,2 cases(6.3%)poor.The good rate Was 87.6%.Conclusions Surgery is effective to trot Tibial plateau fracture.A stable internal fixation,as far as possible,reduces the blood supply to fracture block interference and protects joint subsidiary structure to correct joint function rehabilitation treatment.