1.
Cancer Research and Clinic
;
(6): 427-430, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-382163
ABSTRACT
Hypoxia-inducible factor-alpha-1 (Hif-lalpha) is an active-transcription nucleoprotein produced in cellular hypoxia condition, and HIF-1 can bring tissues into adaptation reaction when the tissues are in state of hypoxis. Apart from that, the factor is involved in angiogenesis of ovarian tumor, energy metabolism, invasive metabasis of the tumor and prognosis. Therefore, a new treatment of ovarian tumor may rely on the thorough study of the relationship between HIF-1 and the tumor by investigating its expression and mechanism.