ABSTRACT
Alzheimer's disease is an age-related neurodegenerative disease, and its pathogenesis has not been fully elucidated.In recent years the role of metal ions in the development and de-velopment of Alzheimer's disease has been brought into foeus.This paper reviews the homeostasis imbalance of metal ions, in- eluding the essential metal ions for human body such as Fe~ + / Fe3+ , CuV Cu2 + , Zn2 + , Mg2 + , as well as non-essential metal ions such as Al '+ and Hg"+ , involved in the pathogenesis of AI), aiming to provide research clues for anti-AD dnig targeting metal ions.
ABSTRACT
Alzheimer's disease is a neurodegenerative disease with multiple causes. Due to no effective drugs to reverse the progress of AD, many researchers in the world focus on the early pathological changes of AD in order to find the effective intervention for delaying the progress of AD. As an organ with high energy demand, brain is very sensitive to changes in fuel supply and energy alteration. Abnormal glucose metabolism and mitochondrial dysfunction are the important signs of brain aging and the main causes of bioenergetic deficits, which appear earlier than the characteristic pathological injuries of AD. So the disturbance of energy synthesis has been considered an early contributory e- vent to AD progression. In this article we review the study progress of energy synthesis disorder involved in the pathogenesis of AD base on cerebral blood flow, glucose uptake, utilization and the relative metabolic regulation in the brain.