1.
China Pharmacy
; (12): 356-357, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410266
ABSTRACT
OBJECTIVE: To study the pharmacokinetics and relative bioavalability of omeprazole capsules in humans.METHODS: 18 male healthy volunteers orally took domestic omeprazole capsules and losec capsulles(used as control)40mg respectively.Blood concentrations of drugs were determined by HPLC.RESULTS: Times to reach the peak levels of omeprazole and losec were (2.10± 0.64) h and (1.88± 0.70) h, the peak plasma concentrations were (895.64± 553.07) ng/ml and (974.67± 554.93) ng/ml and the areas under the drug concentration curves were (1 971.88± 1 220.98 ) ng/(h· ml) and (2 057.60± 1 306.32) ng/(h· ml) respectively.CONCLUSION: The two capsules have the same bioequivalence.