ABSTRACT
Objective: To investigate the clinical effect of Maren Soft Capsule (MSC) in the treatment of constipation induced by antipsychotic drugs. Methods: Totally 192 hospitalized psychiatric patients with constipation caused by antipsychotic drugs were randomly divided into three groups, there wer 64 cases in each group. The first group was treated with MSC, the second group was given Sennae Folium, and the third group was given Phenolphthalein Tablets. The exhaust, defecation time, abdominal pain, and abdominal distension were observed after the treatment. Results: The total effect rates of the three drugs were over 80%. There was no significant difference in the effect of three drugs (P > 0.05), but Sennae Folium and Phenolphthalein Tablets had different degrees of side effects such as diarrhea and abdominal pain. Occurrence of adverse reaction rate of MSC was significantly lower than that of Sennae Folium and Phenolphthalein Tablets (P < 0.01). Conclusion: The effect of MSC in the treatment of antipsychotic drugs-induced constipation is significant, and the incidence of adverse reactions is low.