ABSTRACT
Objective To investigate the efficacy and prognostic factors of non-small cell lung cancer (NSCLC) leptomeningeal metastasis (LM) patients undergoing treatment with epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs).Methods The clinical data of 30 patients with NSCLC- LM were retrospectively analyzed, including the basic situation, survival time, clinical characteristics,pathological type,differentiation degree and treatment method.The median survival time (MOS) was calculated by Kaplan-Meier method. The log-rank test was used to analyze the prognostic single factors.The Cox regression model was used to analyze the multivariate factors. Results The log-rank test result showed that sex,pathological type,differentiation degree and EGFR-TKIs treatment were the influencing factors of MOS(P<0.05).The multivariate analysis result showed that sex,pathological type, differentiation degree and EGFR-TKIs treatment were the independent influencing factors of prognosis in NSCLC-LM patients (P<0.05), and the female gender (RR = 0.090, 95% CI 0.048 -0.140),adenocarcinoma(RR=0.108,95% CI 0.073-0.134),well differentiation(RR=0.112,95% CI 0.076 - 0.141), using EGFR-TKIs treatment (RR = 0.042, 95% CI 0.012 - 0.074) were significant predictors of a good prognosis. Conclusions The female gender, well differentiation, adenocarcinoma and EGFR-TKIs treatments are significant predictors of a good prognosis. EGFR-TKIs can prolong the survival time of patients with NSCLC-LM,and it is recommended for a clinical treatment for patients with NSCLC-LM.