ABSTRACT
@#Objective To explore the effect of Curcumae on acute hepatic injuried mice.Methods The model mice of acute hepatic injury were established with intraperitoneal injecting 0.2% carbon tetrachloride (CCl4) 0.2 ml/10mg. 48 mice were randomized into 6 groups: model group, control group, Ganlixin group (25 mg/kg) and three treating groups of Curcumae which were administrated by gavage at the doses of 2.5 g/kg, 5 g/kg, 10 g/kg once everyday.7 d later, all mice were put to death. The liver index, the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum, the activities of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in hepatic tissue were observed. Pathological change was observed under HE staining. Results Compared with the model group, Curcumae could decrease the liver index and the activities of ALT and AST in serum, MDA in hepatic tissue significantly (P<0.05), and increase the activities of SOD (P<0.05). The pathological changes were less in three treating groups than that of the models. Conclusion Curcumae can protect the liver from acute hepatic injuried induced with CCl4 in mice.
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Objective To Study the antitumor activity of Zhongjiefeng injection(ZJF)on FC in mice with precancer of stomach and its toxicity.Methods The model mice transplanted with pre cancer of stomach was established an d the effects of ZJF on inhibitory rate,body weigh t,thymus index and spleen index,whi te blood cell(WBC)count and FC cell strain in model mice were observed.Results ZJF had an obvious antitumor effect.The inhibitory rates of ZJF ip 0.2g /k g,1g /kg and 2g /kg were 39.83%,64.41%and 53.39%respectively.ZJF increased the indexes of spleen and thymus,the amount of WBC and body weight.The inhibitory rates of ZJF ip 100mg /mL,50mg /mL,25mg /mL,12.5mg /mL and6.25mg /mL were 65%,63%,57%,55%and44%respectively.Conclusion ZJF exerts an in -vitro and in -vivo antitumor effect for precancer of stomach in mice and increase the indexes of immune organs and amount of WBC.
ABSTRACT
Objective: To study antitumor activity of Zhongjiefeng Injection (Herba sarcandrae) on mice liver cancer Hep A 22 in vivo, in vitro and its toxic reaction in mice with Hep A 22 tumor Methods: The antitumor activity and toxicity of Zhongjiefeng Injection were determined in the mice with transplantable tumor (mice liver cancer Hep A 22), and the antitumor effect of Zhongjiefeng Injection on Hep A 22 cells in vitro were determined with MTT method. Conclusion: The experiment indicates that Zhongjiefeng Injection shows significant antitumon effect increase the indexes of immune organs and amounts of WBC.